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The renal handling of calcium and phosphate in relationship to the renal handling of sodium was studied in 7 healthy male volunteers under steady state metabolic conditions during prolonged (10 days) mineralocorticoid treatment. Calcium excretion was reduced together with sodium excretion during the early phase of mineralocorticoid treatment, whereas it increased independent of sodium excretion following the escape. Phosphate excretion did not change throughout. These results suggest that when there is extracellular volume expansion without increase in sodium intake and/or excretion, there is a dissociation of calcium and sodium excretion, suggesting that extracellular volume can affect the renal tubular handling of calcium probably as a result of mechanism(s) operating in the distal nephron.
F P Cappuccio, and
N D Markandu, and
G A MacGregor
November 1972,
Kidney international,
F P Cappuccio, and
N D Markandu, and
G A MacGregor
November 1971,
Revue europeenne d'etudes cliniques et biologiques. European journal of clinical and biological research,
F P Cappuccio, and
N D Markandu, and
G A MacGregor
January 1976,
International review of physiology,
F P Cappuccio, and
N D Markandu, and
G A MacGregor
October 1980,
Klinische Wochenschrift,
F P Cappuccio, and
N D Markandu, and
G A MacGregor
January 1979,
Annual review of physiology,
F P Cappuccio, and
N D Markandu, and
G A MacGregor
January 1981,
Scandinavian journal of urology and nephrology. Supplementum,
F P Cappuccio, and
N D Markandu, and
G A MacGregor
January 1987,
Mineral and electrolyte metabolism,
F P Cappuccio, and
N D Markandu, and
G A MacGregor
July 1985,
Taiwan yi xue hui za zhi. Journal of the Formosan Medical Association,
F P Cappuccio, and
N D Markandu, and
G A MacGregor
December 1997,
Clinical nephrology,
F P Cappuccio, and
N D Markandu, and
G A MacGregor
January 1990,
Seminars in nephrology,
