Biomaterial Database

The effects of apomorphine on the acquisition of schedule-induced polydipsia in rats. 1988

S H Snodgrass, and J D Allen

Department of Psychology, University of Georgia, Athens 30602.

Injections of the dopamine agent, apomorphine, at the doses of 0.05, 0.50 and 1.0 mg/kg were given to three different groups of rats while a fourth group received an injection of the drug vehicle. The injections preceded each of 15 schedule-induced polydipsia (SIP) acquisition sessions in which the subjects bar-pressed for food pellets on a fixed interval 60-sec schedule of reinforcement. The vehicle-injected group developed SIP over sessions while each dose of apomorphine suppressed the acquisition of SIP. Bar-press rates were also depressed at the higher doses, while response patterning was affected at the lower dose. The results support the contention that a normally functioning dopamine system is necessary for the acquisition of SIP, but they do not support the view that this neurotransmitter system is specifically involved in the generation of SIP.

UI	MeSH Term	Description	Entries
D008297	Male		Males
D012055	Reinforcement Schedule	A schedule prescribing when the subject is to be reinforced or rewarded in terms of temporal interval in psychological experiments. The schedule may be continuous or intermittent.	Reinforcement Schedules,Schedule, Reinforcement,Schedules, Reinforcement
D004298	Dopamine	One of the catecholamine NEUROTRANSMITTERS in the brain. It is derived from TYROSINE and is the precursor to NOREPINEPHRINE and EPINEPHRINE. Dopamine is a major transmitter in the extrapyramidal system of the brain, and important in regulating movement. A family of receptors (RECEPTORS, DOPAMINE) mediate its action.	Hydroxytyramine,3,4-Dihydroxyphenethylamine,4-(2-Aminoethyl)-1,2-benzenediol,Dopamine Hydrochloride,Intropin,3,4 Dihydroxyphenethylamine,Hydrochloride, Dopamine
D004327	Drinking Behavior	Behaviors associated with the ingesting of water and other liquids; includes rhythmic patterns of drinking (time intervals - onset and duration), frequency and satiety.	Behavior, Drinking,Behaviors, Drinking,Drinking Behaviors
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D001058	Apomorphine	A derivative of morphine that is a dopamine D2 agonist. It is a powerful emetic and has been used for that effect in acute poisoning. It has also been used in the diagnosis and treatment of parkinsonism, but its adverse effects limit its use.	Apokinon,Apomorphin-Teclapharm,Apomorphine Chloride,Apomorphine Hydrochloride,Apomorphine Hydrochloride Anhydrous,Apomorphine Hydrochloride, Anhydrous,Apomorphine Hydrochloride, Hemihydrate,Britaject,Apomorphin Teclapharm
D051381	Rats	The common name for the genus Rattus.	Rattus,Rats, Laboratory,Rats, Norway,Rattus norvegicus,Laboratory Rat,Laboratory Rats,Norway Rat,Norway Rats,Rat,Rat, Laboratory,Rat, Norway,norvegicus, Rattus