BIOMAT Database Logo BIOMAT Database Logo

Attenuation of pulmonary afferent input by vagal cooling in dogs. 1988

A Jonzon, and T E Pisarri, and A M Roberts, and J C Coleridge, and H M Coleridge
Cardiovascular Research Institute, University of California, San Francisco 94143-0130.

In open chest, artificially ventilated, anesthetized dogs, we examined the effect of vagal cooling on the pulmonary afferent input evoked by hyperinflating the lungs to 3 VT, recording the activity of slowly adapting pulmonary stretch receptors (PSRs), rapidly adapting receptors (RARs) and pulmonary C fibers rostral to the cooling platform. At 15 degrees C and below, input in all three types of fiber was significantly reduced, attenuation being least marked in C fibers. Between 12 degrees C and 7 degrees C, attenuation of RAR input was significantly less than that of PSRs. At 7 degrees C, virtually none of the hyperinflation-evoked increase in PSR activity and only 10% of that in RARs passed the cooling platform--indeed RAR input was less than during normal ventilation at 37 degrees C; by contrast, 40% of the hyperinflation-evoked increase in C fiber activity was still transmitted. Cooling had similar effects on C fiber input evoked by capsaicin. If reflexes are attenuated in proportion to the attenuation of afferent input, our results suggest that a hyperinflation-evoked reflex that survives vagal cooling below 6 degrees C is almost certainly triggered by C fibers.

UI MeSH Term Description Entries
D008168 Lung Either of the pair of organs occupying the cavity of the thorax that effect the aeration of the blood. Lungs
D008465 Mechanoreceptors Cells specialized to transduce mechanical stimuli and relay that information centrally in the nervous system. Mechanoreceptor cells include the INNER EAR hair cells, which mediate hearing and balance, and the various somatosensory receptors, often with non-neural accessory structures. Golgi Tendon Organ,Golgi Tendon Organs,Krause's End Bulb,Krause's End Bulbs,Mechanoreceptor,Mechanoreceptor Cell,Meissner's Corpuscle,Neurotendinous Spindle,Neurotendinous Spindles,Receptors, Stretch,Ruffini's Corpuscle,Ruffini's Corpuscles,Stretch Receptor,Stretch Receptors,Mechanoreceptor Cells,Bulb, Krause's End,Bulbs, Krause's End,Cell, Mechanoreceptor,Cells, Mechanoreceptor,Corpuscle, Meissner's,Corpuscle, Ruffini's,Corpuscles, Ruffini's,End Bulb, Krause's,End Bulbs, Krause's,Krause End Bulb,Krause End Bulbs,Krauses End Bulb,Krauses End Bulbs,Meissner Corpuscle,Meissners Corpuscle,Organ, Golgi Tendon,Organs, Golgi Tendon,Receptor, Stretch,Ruffini Corpuscle,Ruffini Corpuscles,Ruffinis Corpuscle,Ruffinis Corpuscles,Spindle, Neurotendinous,Spindles, Neurotendinous,Tendon Organ, Golgi,Tendon Organs, Golgi
D009412 Nerve Fibers Slender processes of NEURONS, including the AXONS and their glial envelopes (MYELIN SHEATH). Nerve fibers conduct nerve impulses to and from the CENTRAL NERVOUS SYSTEM. Cerebellar Mossy Fibers,Mossy Fibers, Cerebellar,Cerebellar Mossy Fiber,Mossy Fiber, Cerebellar,Nerve Fiber
D009413 Nerve Fibers, Myelinated A class of nerve fibers as defined by their structure, specifically the nerve sheath arrangement. The AXONS of the myelinated nerve fibers are completely encased in a MYELIN SHEATH. They are fibers of relatively large and varied diameters. Their NEURAL CONDUCTION rates are faster than those of the unmyelinated nerve fibers (NERVE FIBERS, UNMYELINATED). Myelinated nerve fibers are present in somatic and autonomic nerves. A Fibers,B Fibers,Fiber, Myelinated Nerve,Fibers, Myelinated Nerve,Myelinated Nerve Fiber,Myelinated Nerve Fibers,Nerve Fiber, Myelinated
D011661 Pulmonary Stretch Receptors Stretch receptors found in the bronchi and bronchioles. Pulmonary stretch receptors are sensors for a reflex which stops inspiration. In humans, the reflex is protective and is probably not activated during normal respiration. Receptors, Pulmonary Stretch,Receptors, Stretch, Pulmonary,Stretch Receptors, Pulmonary,Lung Stretch Receptors,Receptors, Stretch, Lung,Stretch Receptors, Lung,Lung Stretch Receptor,Pulmonary Stretch Receptor,Receptor, Lung Stretch,Receptor, Pulmonary Stretch,Receptors, Lung Stretch,Stretch Receptor, Lung,Stretch Receptor, Pulmonary
D003080 Cold Temperature An absence of warmth or heat or a temperature notably below an accustomed norm. Cold,Cold Temperatures,Temperature, Cold,Temperatures, Cold
D004285 Dogs The domestic dog, Canis familiaris, comprising about 400 breeds, of the carnivore family CANIDAE. They are worldwide in distribution and live in association with people. (Walker's Mammals of the World, 5th ed, p1065) Canis familiaris,Dog
D000344 Afferent Pathways Nerve structures through which impulses are conducted from a peripheral part toward a nerve center. Afferent Pathway,Pathway, Afferent,Pathways, Afferent
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D014630 Vagus Nerve The 10th cranial nerve. The vagus is a mixed nerve which contains somatic afferents (from skin in back of the ear and the external auditory meatus), visceral afferents (from the pharynx, larynx, thorax, and abdomen), parasympathetic efferents (to the thorax and abdomen), and efferents to striated muscle (of the larynx and pharynx). Cranial Nerve X,Pneumogastric Nerve,Tenth Cranial Nerve,Nerve X,Nervus Vagus,Cranial Nerve, Tenth,Cranial Nerves, Tenth,Nerve X, Cranial,Nerve Xs,Nerve, Pneumogastric,Nerve, Tenth Cranial,Nerve, Vagus,Nerves, Pneumogastric,Nerves, Tenth Cranial,Nerves, Vagus,Pneumogastric Nerves,Tenth Cranial Nerves,Vagus Nerves,Vagus, Nervus

Related Publications

A Jonzon, and T E Pisarri, and A M Roberts, and J C Coleridge, and H M Coleridge
Stimulation of pulmonary vagal afferent C-fibers by lung edema in dogs.
April 1986, Circulation research,
A Jonzon, and T E Pisarri, and A M Roberts, and J C Coleridge, and H M Coleridge
Cooling the pulmonary blood in dogs alters activity of pulmonary vagal afferents.
January 1993, Journal of applied physiology (Bethesda, Md. : 1985),
A Jonzon, and T E Pisarri, and A M Roberts, and J C Coleridge, and H M Coleridge
Pulmonary arterial distension and vagal afferent nerve activity in anaesthetized dogs.
March 2004, The Journal of physiology,
A Jonzon, and T E Pisarri, and A M Roberts, and J C Coleridge, and H M Coleridge
Afferent vagal modulation. Clinical studies of visceral sensory input.
July 2001, Autonomic neuroscience : basic & clinical,
A Jonzon, and T E Pisarri, and A M Roberts, and J C Coleridge, and H M Coleridge
Tonically active vagal pulmonary afferent neurones.
December 1965, Life sciences,
A Jonzon, and T E Pisarri, and A M Roberts, and J C Coleridge, and H M Coleridge
Modeling and simulation of vagal afferent input of the cough reflex.
July 2022, Respiratory physiology & neurobiology,
A Jonzon, and T E Pisarri, and A M Roberts, and J C Coleridge, and H M Coleridge
[Vagal afferent fibers of pulmonary origin in chickens].
January 1972, Journal de physiologie,
A Jonzon, and T E Pisarri, and A M Roberts, and J C Coleridge, and H M Coleridge
Electrophysiological-anatomic correlates of ATP-triggered vagal reflex in dogs. II. Vagal afferent traffic.
September 1994, The American journal of physiology,
A Jonzon, and T E Pisarri, and A M Roberts, and J C Coleridge, and H M Coleridge
I. Pulmonary-CO2 ventilatory reflex in dogs: effective range of CO2 and results of vagal cooling.
July 1978, Respiration physiology,
A Jonzon, and T E Pisarri, and A M Roberts, and J C Coleridge, and H M Coleridge
Lack of effect of vagal afferent input on central neural respiratory afterdischarge.
September 1978, Journal of applied physiology: respiratory, environmental and exercise physiology,
Copied contents to your clipboard!