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Hypercupremia has been described in patients undergoing chronic dialysis. To further characterize dialysis-associated hypercupremia, we studied plasma copper (PCu) and ceruloplasmin (Cp) in patients on hemodialysis (n = 20) and peritoneal dialysis (n = 25), in uremic patients (n = 10) not yet on dialysis, and in normal age-matched control subjects (n = 20). PCu was significantly elevated in all three patients groups (mean +/- SD) (20.6 +/- 4.1, 19.8 +/- 4.6, 19.8 +/- 4.9 mumol/L, respectively) vs control subjects (16.5 +/- 2.7 mumol/L). However, Cp levels were not significantly different among the four study groups (330 +/- 60, 320 +/- 70, 370 +/- 100, and 360 +/- 90 mg/L, respectively). Calculated nonceruloplasmin copper was significantly higher in all uremic groups. The measurement of chelatable Cu confirmed the presence of significantly higher extractable Cu in hemodialysis (2.7 +/- 0.6 mumol/L) and peritoneal dialysis patients (2.4 +/- 0.5 mumol/L) than control subjects (1.5 +/- 0.3 mumol/L). Cu is elevated in uremia regardless of dialysis status and this elevation is not accounted for by an increase in plasma ceruloplasmin.
J H Sondheimer, and
S K Mahajan, and
D L Rye, and
D K Abu-Hamdan, and
S D Migdal, and
A S Prasad, and
F D McDonald
October 2003,
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J H Sondheimer, and
S K Mahajan, and
D L Rye, and
D K Abu-Hamdan, and
S D Migdal, and
A S Prasad, and
F D McDonald
December 1988,
Archives internationales de physiologie et de biochimie,
J H Sondheimer, and
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S D Migdal, and
A S Prasad, and
F D McDonald
September 1989,
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J H Sondheimer, and
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D L Rye, and
D K Abu-Hamdan, and
S D Migdal, and
A S Prasad, and
F D McDonald
September 1994,
Clinical science (London, England : 1979),
J H Sondheimer, and
S K Mahajan, and
D L Rye, and
D K Abu-Hamdan, and
S D Migdal, and
A S Prasad, and
F D McDonald
January 1979,
Proceedings of the Clinical Dialysis and Transplant Forum,
J H Sondheimer, and
S K Mahajan, and
D L Rye, and
D K Abu-Hamdan, and
S D Migdal, and
A S Prasad, and
F D McDonald
January 2004,
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J H Sondheimer, and
S K Mahajan, and
D L Rye, and
D K Abu-Hamdan, and
S D Migdal, and
A S Prasad, and
F D McDonald
January 1995,
Nephron,
J H Sondheimer, and
S K Mahajan, and
D L Rye, and
D K Abu-Hamdan, and
S D Migdal, and
A S Prasad, and
F D McDonald
January 1990,
Nephron,
J H Sondheimer, and
S K Mahajan, and
D L Rye, and
D K Abu-Hamdan, and
S D Migdal, and
A S Prasad, and
F D McDonald
August 1979,
Canadian Medical Association journal,
J H Sondheimer, and
S K Mahajan, and
D L Rye, and
D K Abu-Hamdan, and
S D Migdal, and
A S Prasad, and
F D McDonald
January 1981,
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