-transparent.png){kind=logo}
Highly functional virus-specific cellular immune response in asymptomatic SARS-CoV-2 infection. 2021
Nina Le Bert, and
Hannah E Clapham, and
Anthony T Tan, and
Wan Ni Chia, and
Christine Y L Tham, and
Jane M Lim, and
Kamini Kunasegaran, and
Linda Wei Lin Tan, and
Charles-Antoine Dutertre, and
Nivedita Shankar, and
Joey M E Lim, and
Louisa Jin Sun, and
Marina Zahari, and
Zaw Myo Tun, and
Vishakha Kumar, and
Beng Lee Lim, and
Siew Hoon Lim, and
Adeline Chia, and
Yee-Joo Tan, and
Paul Anantharajah Tambyah, and
Shirin Kalimuddin, and
David Lye, and
Jenny G H Low, and
Lin-Fa Wang, and
Wei Yee Wan, and
Li Yang Hsu, and
Antonio Bertoletti, and
Clarence C Tam
Programme in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore.
The efficacy of virus-specific T cells in clearing pathogens involves a fine balance between antiviral and inflammatory features. SARS-CoV-2-specific T cells in individuals who clear SARS-CoV-2 without symptoms could reveal nonpathological yet protective characteristics. We longitudinally studied SARS-CoV-2-specific T cells in a cohort of asymptomatic (n = 85) and symptomatic (n = 75) COVID-19 patients after seroconversion. We quantified T cells reactive to structural proteins (M, NP, and Spike) using ELISpot and cytokine secretion in whole blood. Frequencies of SARS-CoV-2-specific T cells were similar between asymptomatic and symptomatic individuals, but the former showed an increased IFN-γ and IL-2 production. This was associated with a proportional secretion of IL-10 and proinflammatory cytokines (IL-6, TNF-α, and IL-1β) only in asymptomatic infection, while a disproportionate secretion of inflammatory cytokines was triggered by SARS-CoV-2-specific T cell activation in symptomatic individuals. Thus, asymptomatic SARS-CoV-2-infected individuals are not characterized by weak antiviral immunity; on the contrary, they mount a highly functional virus-specific cellular immune response.
Related Publications
Nina Le Bert, and
Hannah E Clapham, and
Anthony T Tan, and
Wan Ni Chia, and
Christine Y L Tham, and
Jane M Lim, and
Kamini Kunasegaran, and
Linda Wei Lin Tan, and
Charles-Antoine Dutertre, and
Nivedita Shankar, and
Joey M E Lim, and
Louisa Jin Sun, and
Marina Zahari, and
Zaw Myo Tun, and
Vishakha Kumar, and
Beng Lee Lim, and
Siew Hoon Lim, and
Adeline Chia, and
Yee-Joo Tan, and
Paul Anantharajah Tambyah, and
Shirin Kalimuddin, and
David Lye, and
Jenny G H Low, and
Lin-Fa Wang, and
Wei Yee Wan, and
Li Yang Hsu, and
Antonio Bertoletti, and
Clarence C Tam
February 2024,
Cellular & molecular immunology,
Nina Le Bert, and
Hannah E Clapham, and
Anthony T Tan, and
Wan Ni Chia, and
Christine Y L Tham, and
Jane M Lim, and
Kamini Kunasegaran, and
Linda Wei Lin Tan, and
Charles-Antoine Dutertre, and
Nivedita Shankar, and
Joey M E Lim, and
Louisa Jin Sun, and
Marina Zahari, and
Zaw Myo Tun, and
Vishakha Kumar, and
Beng Lee Lim, and
Siew Hoon Lim, and
Adeline Chia, and
Yee-Joo Tan, and
Paul Anantharajah Tambyah, and
Shirin Kalimuddin, and
David Lye, and
Jenny G H Low, and
Lin-Fa Wang, and
Wei Yee Wan, and
Li Yang Hsu, and
Antonio Bertoletti, and
Clarence C Tam
September 2020,
The Lancet. Infectious diseases,
Nina Le Bert, and
Hannah E Clapham, and
Anthony T Tan, and
Wan Ni Chia, and
Christine Y L Tham, and
Jane M Lim, and
Kamini Kunasegaran, and
Linda Wei Lin Tan, and
Charles-Antoine Dutertre, and
Nivedita Shankar, and
Joey M E Lim, and
Louisa Jin Sun, and
Marina Zahari, and
Zaw Myo Tun, and
Vishakha Kumar, and
Beng Lee Lim, and
Siew Hoon Lim, and
Adeline Chia, and
Yee-Joo Tan, and
Paul Anantharajah Tambyah, and
Shirin Kalimuddin, and
David Lye, and
Jenny G H Low, and
Lin-Fa Wang, and
Wei Yee Wan, and
Li Yang Hsu, and
Antonio Bertoletti, and
Clarence C Tam
February 2022,
Microorganisms,
Nina Le Bert, and
Hannah E Clapham, and
Anthony T Tan, and
Wan Ni Chia, and
Christine Y L Tham, and
Jane M Lim, and
Kamini Kunasegaran, and
Linda Wei Lin Tan, and
Charles-Antoine Dutertre, and
Nivedita Shankar, and
Joey M E Lim, and
Louisa Jin Sun, and
Marina Zahari, and
Zaw Myo Tun, and
Vishakha Kumar, and
Beng Lee Lim, and
Siew Hoon Lim, and
Adeline Chia, and
Yee-Joo Tan, and
Paul Anantharajah Tambyah, and
Shirin Kalimuddin, and
David Lye, and
Jenny G H Low, and
Lin-Fa Wang, and
Wei Yee Wan, and
Li Yang Hsu, and
Antonio Bertoletti, and
Clarence C Tam
January 2020,
ImmunoTargets and therapy,
Nina Le Bert, and
Hannah E Clapham, and
Anthony T Tan, and
Wan Ni Chia, and
Christine Y L Tham, and
Jane M Lim, and
Kamini Kunasegaran, and
Linda Wei Lin Tan, and
Charles-Antoine Dutertre, and
Nivedita Shankar, and
Joey M E Lim, and
Louisa Jin Sun, and
Marina Zahari, and
Zaw Myo Tun, and
Vishakha Kumar, and
Beng Lee Lim, and
Siew Hoon Lim, and
Adeline Chia, and
Yee-Joo Tan, and
Paul Anantharajah Tambyah, and
Shirin Kalimuddin, and
David Lye, and
Jenny G H Low, and
Lin-Fa Wang, and
Wei Yee Wan, and
Li Yang Hsu, and
Antonio Bertoletti, and
Clarence C Tam
November 2022,
JAMA pediatrics,
Nina Le Bert, and
Hannah E Clapham, and
Anthony T Tan, and
Wan Ni Chia, and
Christine Y L Tham, and
Jane M Lim, and
Kamini Kunasegaran, and
Linda Wei Lin Tan, and
Charles-Antoine Dutertre, and
Nivedita Shankar, and
Joey M E Lim, and
Louisa Jin Sun, and
Marina Zahari, and
Zaw Myo Tun, and
Vishakha Kumar, and
Beng Lee Lim, and
Siew Hoon Lim, and
Adeline Chia, and
Yee-Joo Tan, and
Paul Anantharajah Tambyah, and
Shirin Kalimuddin, and
David Lye, and
Jenny G H Low, and
Lin-Fa Wang, and
Wei Yee Wan, and
Li Yang Hsu, and
Antonio Bertoletti, and
Clarence C Tam
March 2022,
Revista de la Facultad de Ciencias Medicas (Cordoba, Argentina),
Nina Le Bert, and
Hannah E Clapham, and
Anthony T Tan, and
Wan Ni Chia, and
Christine Y L Tham, and
Jane M Lim, and
Kamini Kunasegaran, and
Linda Wei Lin Tan, and
Charles-Antoine Dutertre, and
Nivedita Shankar, and
Joey M E Lim, and
Louisa Jin Sun, and
Marina Zahari, and
Zaw Myo Tun, and
Vishakha Kumar, and
Beng Lee Lim, and
Siew Hoon Lim, and
Adeline Chia, and
Yee-Joo Tan, and
Paul Anantharajah Tambyah, and
Shirin Kalimuddin, and
David Lye, and
Jenny G H Low, and
Lin-Fa Wang, and
Wei Yee Wan, and
Li Yang Hsu, and
Antonio Bertoletti, and
Clarence C Tam
November 2022,
International journal of molecular sciences,
Nina Le Bert, and
Hannah E Clapham, and
Anthony T Tan, and
Wan Ni Chia, and
Christine Y L Tham, and
Jane M Lim, and
Kamini Kunasegaran, and
Linda Wei Lin Tan, and
Charles-Antoine Dutertre, and
Nivedita Shankar, and
Joey M E Lim, and
Louisa Jin Sun, and
Marina Zahari, and
Zaw Myo Tun, and
Vishakha Kumar, and
Beng Lee Lim, and
Siew Hoon Lim, and
Adeline Chia, and
Yee-Joo Tan, and
Paul Anantharajah Tambyah, and
Shirin Kalimuddin, and
David Lye, and
Jenny G H Low, and
Lin-Fa Wang, and
Wei Yee Wan, and
Li Yang Hsu, and
Antonio Bertoletti, and
Clarence C Tam
February 2021,
Emerging infectious diseases,
Nina Le Bert, and
Hannah E Clapham, and
Anthony T Tan, and
Wan Ni Chia, and
Christine Y L Tham, and
Jane M Lim, and
Kamini Kunasegaran, and
Linda Wei Lin Tan, and
Charles-Antoine Dutertre, and
Nivedita Shankar, and
Joey M E Lim, and
Louisa Jin Sun, and
Marina Zahari, and
Zaw Myo Tun, and
Vishakha Kumar, and
Beng Lee Lim, and
Siew Hoon Lim, and
Adeline Chia, and
Yee-Joo Tan, and
Paul Anantharajah Tambyah, and
Shirin Kalimuddin, and
David Lye, and
Jenny G H Low, and
Lin-Fa Wang, and
Wei Yee Wan, and
Li Yang Hsu, and
Antonio Bertoletti, and
Clarence C Tam
February 2022,
EMBO reports,
Nina Le Bert, and
Hannah E Clapham, and
Anthony T Tan, and
Wan Ni Chia, and
Christine Y L Tham, and
Jane M Lim, and
Kamini Kunasegaran, and
Linda Wei Lin Tan, and
Charles-Antoine Dutertre, and
Nivedita Shankar, and
Joey M E Lim, and
Louisa Jin Sun, and
Marina Zahari, and
Zaw Myo Tun, and
Vishakha Kumar, and
Beng Lee Lim, and
Siew Hoon Lim, and
Adeline Chia, and
Yee-Joo Tan, and
Paul Anantharajah Tambyah, and
Shirin Kalimuddin, and
David Lye, and
Jenny G H Low, and
Lin-Fa Wang, and
Wei Yee Wan, and
Li Yang Hsu, and
Antonio Bertoletti, and
Clarence C Tam
June 2021,
Antibodies (Basel, Switzerland),
