-transparent.png){kind=logo}
Effects of dietary lipid hydroperoxides on lymphoid tissue were studied in mice. When graded amounts (190, 270 and 310 mg) of methyl linoleate hydroperoxide (MLHPO) were orally administered to male C57BL/6 mice (6 weeks old), necrosis was observed in lymphocytes located among the reticular network in the thymus, and thymus weight was significantly decreased 24 h after the treatment. The spleen weight of mice given MLHPO tended to decrease. Spontaneous chemiluminescence of the thymus was remarkably increased after the dose. Thiobarbituric acid reactants in the liver, thymus and blood were also increased after the dose of MLHPO. At intervals of 3, 6, 12 and 24 h after a dose of 14C-labeled MLHPO, 14C was detected in the blood and liver. Fatty infiltration of the liver was found after the treatment with MLHPO. These findings indicate that oral intake of lipid hydroperoxides causes significant damage to lymphoid tissues of mice.
M Oarada, and
E Ito, and
K Terao, and
T Miyazawa, and
K Fujimoto, and
T Kaneda
August 2000,
Journal of experimental botany,
M Oarada, and
E Ito, and
K Terao, and
T Miyazawa, and
K Fujimoto, and
T Kaneda
August 1992,
Biochemistry,
M Oarada, and
E Ito, and
K Terao, and
T Miyazawa, and
K Fujimoto, and
T Kaneda
January 1996,
Free radical biology & medicine,
M Oarada, and
E Ito, and
K Terao, and
T Miyazawa, and
K Fujimoto, and
T Kaneda
November 1989,
Agents and actions,
M Oarada, and
E Ito, and
K Terao, and
T Miyazawa, and
K Fujimoto, and
T Kaneda
February 1994,
Biochemistry and molecular biology international,
M Oarada, and
E Ito, and
K Terao, and
T Miyazawa, and
K Fujimoto, and
T Kaneda
December 1989,
Chemical & pharmaceutical bulletin,
M Oarada, and
E Ito, and
K Terao, and
T Miyazawa, and
K Fujimoto, and
T Kaneda
November 1987,
Japanese journal of cancer research : Gann,
M Oarada, and
E Ito, and
K Terao, and
T Miyazawa, and
K Fujimoto, and
T Kaneda
April 1978,
Developmental and comparative immunology,
M Oarada, and
E Ito, and
K Terao, and
T Miyazawa, and
K Fujimoto, and
T Kaneda
February 1974,
Proceedings of the Royal Society of London. Series B, Biological sciences,
M Oarada, and
E Ito, and
K Terao, and
T Miyazawa, and
K Fujimoto, and
T Kaneda
May 1985,
Biochemical pharmacology,
