Whole-body vibration therapy does not improve the peripheral nerve regeneration in experimental model. 2021

Charlanne de Oliveira Marques, and Izabela Amaro Espindula, and Eric Kwame Karikari Darko, and Leandro Viçosa Bonetti, and Anelise Sonza, and Wania Aparecida Partata, and Maria Cristina Faccioni-Heuser, and Taís Malysz
Post graduation Program in Neuroscience, Institute of Basic Health Sciences, Federal University of Rio Grande do Sul, Rio Grande do Sul, Brazil.

Whole-body vibration (WBV) is commonly used to improve motor function, balance and functional performance, but its effects on the body are not fully understood. The main objective was to evaluate the morphometric and functional effects of WBV in an experimental nerve regeneration model. Wistar rats were submitted to unilateral sciatic nerve crush and treated with WBV (4-5 weeks), started at 3 or 10 days after injury. Functional performances were weekly assessed by sciatic functional index, horizontal ladder rung walking and narrow beam tests. Nerve histomorphometry analysis was assessed at the end of the protocol. Injured groups, sedentary and WBV started at 3 days, had similar functional deficits. WBV, regardless of the start time, did not alter the histomorphometry parameters in the regeneration process. The earlier therapy did not change the expected and natural recovery after the nerve lesion, but when the WBV starts later it seems to impair function parameter of recovery.

UI MeSH Term Description Entries
D008297 Male Males
D009416 Nerve Regeneration Renewal or physiological repair of damaged nerve tissue. Nerve Tissue Regeneration,Nervous Tissue Regeneration,Neural Tissue Regeneration,Nerve Tissue Regenerations,Nervous Tissue Regenerations,Neural Tissue Regenerations,Regeneration, Nerve,Regeneration, Nerve Tissue,Regeneration, Nervous Tissue,Regeneration, Neural Tissue,Tissue Regeneration, Nerve,Tissue Regeneration, Nervous,Tissue Regeneration, Neural
D010525 Peripheral Nerves The nerves outside of the brain and spinal cord, including the autonomic, cranial, and spinal nerves. Peripheral nerves contain non-neuronal cells and connective tissue as well as axons. The connective tissue layers include, from the outside to the inside, the epineurium, the perineurium, and the endoneurium. Endoneurium,Epineurium,Perineurium,Endoneuriums,Epineuriums,Nerve, Peripheral,Nerves, Peripheral,Perineuriums,Peripheral Nerve
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D014732 Vibration A continuing periodic change in displacement with respect to a fixed reference. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed) Vibrations
D017208 Rats, Wistar A strain of albino rat developed at the Wistar Institute that has spread widely at other institutions. This has markedly diluted the original strain. Wistar Rat,Rat, Wistar,Wistar Rats
D051381 Rats The common name for the genus Rattus. Rattus,Rats, Laboratory,Rats, Norway,Rattus norvegicus,Laboratory Rat,Laboratory Rats,Norway Rat,Norway Rats,Rat,Rat, Laboratory,Rat, Norway,norvegicus, Rattus
D020127 Recovery of Function A partial or complete return to the normal or proper physiologic activity of an organ or part following disease or trauma. Function Recoveries,Function Recovery
D020426 Sciatic Neuropathy Disease or damage involving the SCIATIC NERVE, which divides into the PERONEAL NERVE and TIBIAL NERVE (see also PERONEAL NEUROPATHIES and TIBIAL NEUROPATHY). Clinical manifestations may include SCIATICA or pain localized to the hip, PARESIS or PARALYSIS of posterior thigh muscles and muscles innervated by the peroneal and tibial nerves, and sensory loss involving the lateral and posterior thigh, posterior and lateral leg, and sole of the foot. The sciatic nerve may be affected by trauma; ISCHEMIA; COLLAGEN DISEASES; and other conditions. (From Adams et al., Principles of Neurology, 6th ed, p1363) Sciatic Nerve Diseases,Lesion of Sciatic Nerve,Neuralgia-Neuritis, Sciatic Nerve,Sciatic Nerve Palsy,Sciatic Neuritis,Nerve Disease, Sciatic,Nerve Diseases, Sciatic,Nerve Lesion, Sciatic,Nerve Lesions, Sciatic,Nerve Palsies, Sciatic,Nerve Palsy, Sciatic,Neuralgia Neuritis, Sciatic Nerve,Neuralgia-Neuritides, Sciatic Nerve,Neuritides, Sciatic,Neuritis, Sciatic,Neuropathies, Sciatic,Neuropathy, Sciatic,Palsies, Sciatic Nerve,Palsy, Sciatic Nerve,Sciatic Nerve Disease,Sciatic Nerve Lesion,Sciatic Nerve Lesions,Sciatic Nerve Neuralgia-Neuritides,Sciatic Nerve Neuralgia-Neuritis,Sciatic Nerve Palsies,Sciatic Neuritides,Sciatic Neuropathies

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