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Two hundred and twelve individuals who failed to respond or responded poorly to hepatitis B vaccination or whose anti-HBs levels had dropped below 10 IU/L at follow-up were revaccinated. Only 18% of initial nonresponders, but 96% of those who responded initially, developed anti-HBs above 10 IU/L after revaccination. In 85% of vaccinees, anti-HBs titres after a fourth immunization were significantly higher than after completion of the first full immunization course, and despite a steeper decline of antibody levels after revaccination, anti-HBs seemed to persist better than after the initial course of three inoculations. All individuals who responded initially and in whom anti-HBs had become undetectable developed antibodies. Response to booster doses was seen after three to five days, and a fifth inoculation given to 23 individuals induced even better responses.
W Jilg, and
M Schmidt, and
F Deinhardt
October 1992,
Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi,
W Jilg, and
M Schmidt, and
F Deinhardt
February 1995,
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America,
W Jilg, and
M Schmidt, and
F Deinhardt
July 1991,
Lancet (London, England),
W Jilg, and
M Schmidt, and
F Deinhardt
January 1980,
Acta gastro-enterologica Belgica,
W Jilg, and
M Schmidt, and
F Deinhardt
August 1991,
Lancet (London, England),
W Jilg, and
M Schmidt, and
F Deinhardt
January 1992,
Vaccine,
W Jilg, and
M Schmidt, and
F Deinhardt
September 2012,
Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine],
W Jilg, and
M Schmidt, and
F Deinhardt
January 1975,
Infection and immunity,
W Jilg, and
M Schmidt, and
F Deinhardt
January 1987,
Postgraduate medical journal,
W Jilg, and
M Schmidt, and
F Deinhardt
January 2015,
Human vaccines & immunotherapeutics,
