The Potential of Hydrogen Sulfide Donors in Treating Cardiovascular Diseases. 2021

Yi-Zhen Wang, and Ebenezeri Erasto Ngowi, and Di Wang, and Hui-Wen Qi, and Mi-Rong Jing, and Yan-Xia Zhang, and Chun-Bo Cai, and Qing-Lin He, and Saadullah Khattak, and Nazeer Hussain Khan, and Qi-Ying Jiang, and Xin-Ying Ji, and Dong-Dong Wu
Henan International Joint Laboratory for Nuclear Protein Regulation, School of Basic Medical Sciences, Henan University, Kaifeng 475004, China.

Hydrogen sulfide (H2S) has long been considered as a toxic gas, but as research progressed, the idea has been updated and it has now been shown to have potent protective effects at reasonable concentrations. H2S is an endogenous gas signaling molecule in mammals and is produced by specific enzymes in different cell types. An increasing number of studies indicate that H2S plays an important role in cardiovascular homeostasis, and in most cases, H2S has been reported to be downregulated in cardiovascular diseases (CVDs). Similarly, in preclinical studies, H2S has been shown to prevent CVDs and improve heart function after heart failure. Recently, many H2S donors have been synthesized and tested in cellular and animal models. Moreover, numerous molecular mechanisms have been proposed to demonstrate the effects of these donors. In this review, we will provide an update on the role of H2S in cardiovascular activities and its involvement in pathological states, with a special focus on the roles of exogenous H2S in cardiac protection.

UI MeSH Term Description Entries
D002317 Cardiovascular Agents Agents that affect the rate or intensity of cardiac contraction, blood vessel diameter, or blood volume. Cardioactive Agent,Cardioactive Drug,Cardiovascular Agent,Cardiovascular Drug,Cardioactive Agents,Cardioactive Drugs,Cardiovascular Drugs,Agent, Cardioactive,Agent, Cardiovascular,Drug, Cardioactive,Drug, Cardiovascular
D002318 Cardiovascular Diseases Pathological conditions involving the CARDIOVASCULAR SYSTEM including the HEART; the BLOOD VESSELS; or the PERICARDIUM. Adverse Cardiac Event,Cardiac Events,Major Adverse Cardiac Events,Adverse Cardiac Events,Cardiac Event,Cardiac Event, Adverse,Cardiac Events, Adverse,Cardiovascular Disease,Disease, Cardiovascular,Event, Cardiac
D002465 Cell Movement The movement of cells from one location to another. Distinguish from CYTOKINESIS which is the process of dividing the CYTOPLASM of a cell. Cell Migration,Locomotion, Cell,Migration, Cell,Motility, Cell,Movement, Cell,Cell Locomotion,Cell Motility,Cell Movements,Movements, Cell
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D006862 Hydrogen Sulfide A flammable, poisonous gas with a characteristic odor of rotten eggs. It is used in the manufacture of chemicals, in metallurgy, and as an analytical reagent. (From Merck Index, 11th ed) Hydrogen Sulfide (H2(Sx)),Hydrogen Sulfide (H2S2),Hydrogen Sulfide (H2S3),Sulfide, Hydrogen
D000280 Administration, Inhalation The administration of drugs by the respiratory route. It includes insufflation into the respiratory tract. Drug Administration, Inhalation,Drug Administration, Respiratory,Drug Aerosol Therapy,Inhalation Drug Administration,Inhalation of Drugs,Respiratory Drug Administration,Aerosol Drug Therapy,Aerosol Therapy, Drug,Drug Therapy, Aerosol,Inhalation Administration,Administration, Inhalation Drug,Administration, Respiratory Drug,Therapy, Aerosol Drug,Therapy, Drug Aerosol
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D018384 Oxidative Stress A disturbance in the prooxidant-antioxidant balance in favor of the former, leading to potential damage. Indicators of oxidative stress include damaged DNA bases, protein oxidation products, and lipid peroxidation products (Sies, Oxidative Stress, 1991, pxv-xvi). Anti-oxidative Stress,Antioxidative Stress,DNA Oxidative Damage,Nitro-Oxidative Stress,Oxidative Cleavage,Oxidative DNA Damage,Oxidative Damage,Oxidative Injury,Oxidative Nitrative Stress,Oxidative Stress Injury,Oxidative and Nitrosative Stress,Stress, Oxidative,Anti oxidative Stress,Anti-oxidative Stresses,Antioxidative Stresses,Cleavage, Oxidative,DNA Damage, Oxidative,DNA Oxidative Damages,Damage, DNA Oxidative,Damage, Oxidative,Damage, Oxidative DNA,Injury, Oxidative,Injury, Oxidative Stress,Nitrative Stress, Oxidative,Nitro Oxidative Stress,Nitro-Oxidative Stresses,Oxidative Cleavages,Oxidative DNA Damages,Oxidative Damage, DNA,Oxidative Damages,Oxidative Injuries,Oxidative Nitrative Stresses,Oxidative Stress Injuries,Oxidative Stresses,Stress Injury, Oxidative,Stress, Anti-oxidative,Stress, Antioxidative,Stress, Nitro-Oxidative,Stress, Oxidative Nitrative,Stresses, Nitro-Oxidative
D018919 Neovascularization, Physiologic The development of new BLOOD VESSELS during the restoration of BLOOD CIRCULATION during the healing process. Angiogenesis, Physiologic,Angiogenesis, Physiological,Neovascularization, Physiological,Physiologic Angiogenesis,Physiologic Neovascularization,Physiological Angiogenesis,Physiological Neovascularization

Related Publications

Yi-Zhen Wang, and Ebenezeri Erasto Ngowi, and Di Wang, and Hui-Wen Qi, and Mi-Rong Jing, and Yan-Xia Zhang, and Chun-Bo Cai, and Qing-Lin He, and Saadullah Khattak, and Nazeer Hussain Khan, and Qi-Ying Jiang, and Xin-Ying Ji, and Dong-Dong Wu
January 2018, Frontiers in pharmacology,
Yi-Zhen Wang, and Ebenezeri Erasto Ngowi, and Di Wang, and Hui-Wen Qi, and Mi-Rong Jing, and Yan-Xia Zhang, and Chun-Bo Cai, and Qing-Lin He, and Saadullah Khattak, and Nazeer Hussain Khan, and Qi-Ying Jiang, and Xin-Ying Ji, and Dong-Dong Wu
November 2020, European journal of medicinal chemistry,
Yi-Zhen Wang, and Ebenezeri Erasto Ngowi, and Di Wang, and Hui-Wen Qi, and Mi-Rong Jing, and Yan-Xia Zhang, and Chun-Bo Cai, and Qing-Lin He, and Saadullah Khattak, and Nazeer Hussain Khan, and Qi-Ying Jiang, and Xin-Ying Ji, and Dong-Dong Wu
February 2020, Biomolecules,
Yi-Zhen Wang, and Ebenezeri Erasto Ngowi, and Di Wang, and Hui-Wen Qi, and Mi-Rong Jing, and Yan-Xia Zhang, and Chun-Bo Cai, and Qing-Lin He, and Saadullah Khattak, and Nazeer Hussain Khan, and Qi-Ying Jiang, and Xin-Ying Ji, and Dong-Dong Wu
January 2020, Frontiers in pharmacology,
Yi-Zhen Wang, and Ebenezeri Erasto Ngowi, and Di Wang, and Hui-Wen Qi, and Mi-Rong Jing, and Yan-Xia Zhang, and Chun-Bo Cai, and Qing-Lin He, and Saadullah Khattak, and Nazeer Hussain Khan, and Qi-Ying Jiang, and Xin-Ying Ji, and Dong-Dong Wu
March 2016, Frontiers of medicine,
Yi-Zhen Wang, and Ebenezeri Erasto Ngowi, and Di Wang, and Hui-Wen Qi, and Mi-Rong Jing, and Yan-Xia Zhang, and Chun-Bo Cai, and Qing-Lin He, and Saadullah Khattak, and Nazeer Hussain Khan, and Qi-Ying Jiang, and Xin-Ying Ji, and Dong-Dong Wu
January 2023, Antioxidants & redox signaling,
Yi-Zhen Wang, and Ebenezeri Erasto Ngowi, and Di Wang, and Hui-Wen Qi, and Mi-Rong Jing, and Yan-Xia Zhang, and Chun-Bo Cai, and Qing-Lin He, and Saadullah Khattak, and Nazeer Hussain Khan, and Qi-Ying Jiang, and Xin-Ying Ji, and Dong-Dong Wu
February 2020, Cardiovascular drugs and therapy,
Yi-Zhen Wang, and Ebenezeri Erasto Ngowi, and Di Wang, and Hui-Wen Qi, and Mi-Rong Jing, and Yan-Xia Zhang, and Chun-Bo Cai, and Qing-Lin He, and Saadullah Khattak, and Nazeer Hussain Khan, and Qi-Ying Jiang, and Xin-Ying Ji, and Dong-Dong Wu
September 2009, Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics,
Yi-Zhen Wang, and Ebenezeri Erasto Ngowi, and Di Wang, and Hui-Wen Qi, and Mi-Rong Jing, and Yan-Xia Zhang, and Chun-Bo Cai, and Qing-Lin He, and Saadullah Khattak, and Nazeer Hussain Khan, and Qi-Ying Jiang, and Xin-Ying Ji, and Dong-Dong Wu
April 2016, American journal of physiology. Heart and circulatory physiology,
Yi-Zhen Wang, and Ebenezeri Erasto Ngowi, and Di Wang, and Hui-Wen Qi, and Mi-Rong Jing, and Yan-Xia Zhang, and Chun-Bo Cai, and Qing-Lin He, and Saadullah Khattak, and Nazeer Hussain Khan, and Qi-Ying Jiang, and Xin-Ying Ji, and Dong-Dong Wu
January 2017, Organic letters,
Copied contents to your clipboard!