Biomaterial Database

Efficacy and safety of acellular pertussis vaccine in Aichi Prefecture, Japan. 1988

S Isomura

Aichi Prefectural Institute of Public Health, Nagoya, Japan.

A prominent increase of notified cases of pertussis was observed during discontinuation of pertussis immunization in Aichi Prefecture from 1975 to 1979. The patients were principally unimmunized children. After reintroduction of pertussis vaccine the number of cases decreased gradually and the decline has continued after the introduction of acellular pertussis vaccine. A retrospective survey of immunized schoolchildren also showed efficacy of the vaccine. To confirm the efficacy of acellular vaccine a prospective case contact study was conducted. Of 35 unimmunized children 29 developed clinically diagnosed pertussis, and of 52 children who received two or more doses of the vaccine only two developed disease after the household exposure. There were no serious systemic adverse reactions including high fever or encephalopathy. Severe local reaction occurred in 2.65/100,000 recipients of a third and fourth dose of the acellular vaccine.

UI	MeSH Term	Description	Entries
D007115	Immunization Schedule	Schedule giving optimum times usually for primary and/or secondary immunization.	Immunization Schedules,Schedule, Immunization,Schedules, Immunization
D007564	Japan	A country in eastern Asia, island chain between the North Pacific Ocean and the Sea of Japan, east of the Korean Peninsula. The capital is Tokyo.	Bonin Islands
D010567	Pertussis Vaccine	A suspension of killed Bordetella pertussis organisms, used for immunization against pertussis (WHOOPING COUGH). It is generally used in a mixture with diphtheria and tetanus toxoids (DTP). There is an acellular pertussis vaccine prepared from the purified antigenic components of Bordetella pertussis, which causes fewer adverse reactions than whole-cell vaccine and, like the whole-cell vaccine, is generally used in a mixture with diphtheria and tetanus toxoids. (From Dorland, 28th ed)	Vaccine, Pertussis
D011446	Prospective Studies	Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.	Prospective Study,Studies, Prospective,Study, Prospective
D002648	Child	A person 6 to 12 years of age. An individual 2 to 5 years old is CHILD, PRESCHOOL.	Children
D002675	Child, Preschool	A child between the ages of 2 and 5.	Children, Preschool,Preschool Child,Preschool Children
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D012189	Retrospective Studies	Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.	Retrospective Study,Studies, Retrospective,Study, Retrospective
D014917	Whooping Cough	A respiratory infection caused by BORDETELLA PERTUSSIS and characterized by paroxysmal coughing ending in a prolonged crowing intake of breath.	Pertussis,Bordetella pertussis Infection, Respiratory,Cough, Whooping,Pertusses