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The autoimmune dermatologic disease pemphigus vulgaris (PV) is associated with the HLA serotypes DR4 and DRw6. Susceptibility to PV could be conferred either by sequences shared between the DR4 and DRw6 haplotypes or by different sequences in these haplotypes. We have examined the distribution of DR and DQ beta-chain and DQ alpha-chain alleles in PV patients and in control subjects by hybridization with oligonucleotide probes and sequence analysis of in vitro amplified DNA. Ninety percent (34/38) of the DR4 haplotypes in patients contain a specific DR beta I sequence present in 36% (16 of 44) of DR4 controls (P = 0.001). This sequence is also found in DRw6 haplotypes. However, it is present in only 25% (6 of 24) of DRw6 patients. The results of our analysis indicate that predisposition to PV is conferred by different sequences in DR4 and DRw6 haplotypes. The DR4 susceptibility is highly associated with the Dw10 DR beta I allele, implicating the polymorphic residues in the third hypervariable region. The DRw6 susceptibility is strongly associated with a rare DQ beta allele (DQB1.3). This allele differs from a common DQ beta allele (DQB1.1) only by a valine----aspartic acid substitution at position 57.
S J Scharf, and
A Friedmann, and
C Brautbar, and
F Szafer, and
L Steinman, and
G Horn, and
U Gyllensten, and
H A Erlich
December 2014,
International journal of dermatology,
S J Scharf, and
A Friedmann, and
C Brautbar, and
F Szafer, and
L Steinman, and
G Horn, and
U Gyllensten, and
H A Erlich
August 1992,
Journal of the American Academy of Dermatology,
S J Scharf, and
A Friedmann, and
C Brautbar, and
F Szafer, and
L Steinman, and
G Horn, and
U Gyllensten, and
H A Erlich
October 2006,
Actas dermo-sifiliograficas,
S J Scharf, and
A Friedmann, and
C Brautbar, and
F Szafer, and
L Steinman, and
G Horn, and
U Gyllensten, and
H A Erlich
December 1987,
Transplantation,
S J Scharf, and
A Friedmann, and
C Brautbar, and
F Szafer, and
L Steinman, and
G Horn, and
U Gyllensten, and
H A Erlich
January 1995,
Acta dermato-venereologica,
S J Scharf, and
A Friedmann, and
C Brautbar, and
F Szafer, and
L Steinman, and
G Horn, and
U Gyllensten, and
H A Erlich
August 2000,
Journal of autoimmunity,
S J Scharf, and
A Friedmann, and
C Brautbar, and
F Szafer, and
L Steinman, and
G Horn, and
U Gyllensten, and
H A Erlich
January 1999,
Medicina,
S J Scharf, and
A Friedmann, and
C Brautbar, and
F Szafer, and
L Steinman, and
G Horn, and
U Gyllensten, and
H A Erlich
August 1989,
Proceedings of the National Academy of Sciences of the United States of America,
S J Scharf, and
A Friedmann, and
C Brautbar, and
F Szafer, and
L Steinman, and
G Horn, and
U Gyllensten, and
H A Erlich
September 1998,
Tissue antigens,
S J Scharf, and
A Friedmann, and
C Brautbar, and
F Szafer, and
L Steinman, and
G Horn, and
U Gyllensten, and
H A Erlich
July 1998,
Tissue antigens,
