Design, synthesis, biological evaluation and docking study of novel quinazoline derivatives as EGFR-TK inhibitors. 2021

Hao Jin, and Bai-Xu Wu, and Quan Zheng, and Cheng-Hai Hu, and Xiang-Zheng Tang, and Wen Zhang, and Guo-Wu Rao
College of Pharmaceutical Science, Zhejiang University of Technology & Institute of Drug Development & Chemical Biology, Zhejiang University of Technology, Hangzhou 310014, PR China.

Background: Quinazoline-based compounds have been proved effective in the treatment of cancers for years. Materials & methods: The structural features of several inhibitors of EGFR were integrated and quinazolines with a benzazepine moiety at the 4-position were constructed. Results: Most of the compounds exhibited excellent antitumor activities. Compound 33e showed excellent antitumor activities against the four tested cell lines (IC50: 1.06-3.55 μM). The enzymatic, signaling pathways and apoptosis assay of 33e were subsequently carried out to study the action of the mechanism. Conclusion: Compound 33e with a benzazepine moiety at the 4-position can be screened in this study and provides useful information for the design of EGFR-T790M inhibitors, which deserve additional research.

UI MeSH Term Description Entries
D008958 Models, Molecular Models used experimentally or theoretically to study molecular shape, electronic properties, or interactions; includes analogous molecules, computer-generated graphics, and mechanical structures. Molecular Models,Model, Molecular,Molecular Model
D011799 Quinazolines A group of aromatic heterocyclic compounds that contain a bicyclic structure with two fused six-membered aromatic rings, a benzene ring and a pyrimidine ring. Quinazoline
D002470 Cell Survival The span of viability of a cell characterized by the capacity to perform certain functions such as metabolism, growth, reproduction, some form of responsiveness, and adaptability. Cell Viability,Cell Viabilities,Survival, Cell,Viabilities, Cell,Viability, Cell
D004354 Drug Screening Assays, Antitumor Methods of investigating the effectiveness of anticancer cytotoxic drugs and biologic inhibitors. These include in vitro cell-kill models and cytostatic dye exclusion tests as well as in vivo measurement of tumor growth parameters in laboratory animals. Anticancer Drug Sensitivity Tests,Antitumor Drug Screens,Cancer Drug Tests,Drug Screening Tests, Tumor-Specific,Dye Exclusion Assays, Antitumor,Anti-Cancer Drug Screens,Antitumor Drug Screening Assays,Tumor-Specific Drug Screening Tests,Anti Cancer Drug Screens,Anti-Cancer Drug Screen,Antitumor Drug Screen,Cancer Drug Test,Drug Screen, Anti-Cancer,Drug Screen, Antitumor,Drug Screening Tests, Tumor Specific,Drug Screens, Anti-Cancer,Drug Screens, Antitumor,Drug Test, Cancer,Drug Tests, Cancer,Screen, Anti-Cancer Drug,Screen, Antitumor Drug,Screens, Anti-Cancer Drug,Screens, Antitumor Drug,Test, Cancer Drug,Tests, Cancer Drug,Tumor Specific Drug Screening Tests
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000970 Antineoplastic Agents Substances that inhibit or prevent the proliferation of NEOPLASMS. Anticancer Agent,Antineoplastic,Antineoplastic Agent,Antineoplastic Drug,Antitumor Agent,Antitumor Drug,Cancer Chemotherapy Agent,Cancer Chemotherapy Drug,Anticancer Agents,Antineoplastic Drugs,Antineoplastics,Antitumor Agents,Antitumor Drugs,Cancer Chemotherapy Agents,Cancer Chemotherapy Drugs,Chemotherapeutic Anticancer Agents,Chemotherapeutic Anticancer Drug,Agent, Anticancer,Agent, Antineoplastic,Agent, Antitumor,Agent, Cancer Chemotherapy,Agents, Anticancer,Agents, Antineoplastic,Agents, Antitumor,Agents, Cancer Chemotherapy,Agents, Chemotherapeutic Anticancer,Chemotherapy Agent, Cancer,Chemotherapy Agents, Cancer,Chemotherapy Drug, Cancer,Chemotherapy Drugs, Cancer,Drug, Antineoplastic,Drug, Antitumor,Drug, Cancer Chemotherapy,Drug, Chemotherapeutic Anticancer,Drugs, Antineoplastic,Drugs, Antitumor,Drugs, Cancer Chemotherapy
D015394 Molecular Structure The location of the atoms, groups or ions relative to one another in a molecule, as well as the number, type and location of covalent bonds. Structure, Molecular,Molecular Structures,Structures, Molecular
D017209 Apoptosis A regulated cell death mechanism characterized by distinctive morphologic changes in the nucleus and cytoplasm, including the endonucleolytic cleavage of genomic DNA, at regularly spaced, internucleosomal sites, i.e., DNA FRAGMENTATION. It is genetically programmed and serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth. Apoptosis, Extrinsic Pathway,Apoptosis, Intrinsic Pathway,Caspase-Dependent Apoptosis,Classic Apoptosis,Classical Apoptosis,Programmed Cell Death,Programmed Cell Death, Type I,Apoptoses, Extrinsic Pathway,Apoptoses, Intrinsic Pathway,Apoptosis, Caspase-Dependent,Apoptosis, Classic,Apoptosis, Classical,Caspase Dependent Apoptosis,Cell Death, Programmed,Classic Apoptoses,Extrinsic Pathway Apoptoses,Extrinsic Pathway Apoptosis,Intrinsic Pathway Apoptoses,Intrinsic Pathway Apoptosis
D045744 Cell Line, Tumor A cell line derived from cultured tumor cells. Tumor Cell Line,Cell Lines, Tumor,Line, Tumor Cell,Lines, Tumor Cell,Tumor Cell Lines
D047428 Protein Kinase Inhibitors Agents that inhibit PROTEIN KINASES. Protein Kinase Inhibitor,Inhibitor, Protein Kinase,Inhibitors, Protein Kinase,Kinase Inhibitor, Protein,Kinase Inhibitors, Protein

Related Publications

Hao Jin, and Bai-Xu Wu, and Quan Zheng, and Cheng-Hai Hu, and Xiang-Zheng Tang, and Wen Zhang, and Guo-Wu Rao
September 2019, Bioorganic chemistry,
Hao Jin, and Bai-Xu Wu, and Quan Zheng, and Cheng-Hai Hu, and Xiang-Zheng Tang, and Wen Zhang, and Guo-Wu Rao
September 2010, European journal of medicinal chemistry,
Hao Jin, and Bai-Xu Wu, and Quan Zheng, and Cheng-Hai Hu, and Xiang-Zheng Tang, and Wen Zhang, and Guo-Wu Rao
May 2024, Bioorganic & medicinal chemistry letters,
Hao Jin, and Bai-Xu Wu, and Quan Zheng, and Cheng-Hai Hu, and Xiang-Zheng Tang, and Wen Zhang, and Guo-Wu Rao
April 2021, European journal of medicinal chemistry,
Hao Jin, and Bai-Xu Wu, and Quan Zheng, and Cheng-Hai Hu, and Xiang-Zheng Tang, and Wen Zhang, and Guo-Wu Rao
April 2022, Bioorganic chemistry,
Hao Jin, and Bai-Xu Wu, and Quan Zheng, and Cheng-Hai Hu, and Xiang-Zheng Tang, and Wen Zhang, and Guo-Wu Rao
September 2023, Heliyon,
Hao Jin, and Bai-Xu Wu, and Quan Zheng, and Cheng-Hai Hu, and Xiang-Zheng Tang, and Wen Zhang, and Guo-Wu Rao
March 2024, Scientific reports,
Hao Jin, and Bai-Xu Wu, and Quan Zheng, and Cheng-Hai Hu, and Xiang-Zheng Tang, and Wen Zhang, and Guo-Wu Rao
October 2022, Bioorganic chemistry,
Hao Jin, and Bai-Xu Wu, and Quan Zheng, and Cheng-Hai Hu, and Xiang-Zheng Tang, and Wen Zhang, and Guo-Wu Rao
May 2021, Bioorganic chemistry,
Hao Jin, and Bai-Xu Wu, and Quan Zheng, and Cheng-Hai Hu, and Xiang-Zheng Tang, and Wen Zhang, and Guo-Wu Rao
December 2021, Bioorganic chemistry,
Copied contents to your clipboard!