BIOMAT Database Logo BIOMAT Database Logo

Comparative study on the carcinogenicity of N-nitrosodiethylamine, N-nitrosodimethylamine, N-nitrosomorpholine, N-nitrosopyrrolidine and N-nitrosodi-n-propylamine to the lung of Syrian golden hamsters following intermittent instillations to the trachea. 1988

N Ishinishi, and A Tanaka, and A Hisanaga, and T Inamasu, and M Hirata
Department of Hygiene, Faculty of Medicine, Kyushu University, Fukuoka, Japan.

N-Nitrosodiethylamine (NDEA), N-nitrosodimethylamine (NDMA), N-nitrosomorpholine (NMOR), N-nitrosopyrrolidine (NPYR) and N-nitrosodi-n-propylamine (NDPA) were instilled into the lungs of male Syrian golden hamsters by intratracheal instillations once a week for 15 weeks. The total doses given were 1.5 mg of each drug. As a control, hamsters were treated with the vehicle, phosphate buffer solution. During the total lifespan, tumor incidence rates in the respiratory organs were 100% in the NDEA group, 6% in the NDMA group, 43% in the NMOR group, 0% in the NPYR group, 72% in the NDPA group and 4% in the control group. The incidence rates in the liver were 19% in the NDMA group and 4% in the NPYR group. No liver tumors developed in the other groups. The carcinogenic potencies of these N-nitroso compounds to the respiratory organs was provisionally estimated to be in the following order: NDEA greater than NDPA greater than NMOR greater than NDMA = NPYR, at the 1.5 mg dosage level. However, the difference in the rates of tumor incidence between the NDMA or NPYR group and the control group was not significant.

UI MeSH Term Description Entries
D008113 Liver Neoplasms Tumors or cancer of the LIVER. Cancer of Liver,Hepatic Cancer,Liver Cancer,Cancer of the Liver,Cancer, Hepatocellular,Hepatic Neoplasms,Hepatocellular Cancer,Neoplasms, Hepatic,Neoplasms, Liver,Cancer, Hepatic,Cancer, Liver,Cancers, Hepatic,Cancers, Hepatocellular,Cancers, Liver,Hepatic Cancers,Hepatic Neoplasm,Hepatocellular Cancers,Liver Cancers,Liver Neoplasm,Neoplasm, Hepatic,Neoplasm, Liver
D008175 Lung Neoplasms Tumors or cancer of the LUNG. Cancer of Lung,Lung Cancer,Pulmonary Cancer,Pulmonary Neoplasms,Cancer of the Lung,Neoplasms, Lung,Neoplasms, Pulmonary,Cancer, Lung,Cancer, Pulmonary,Cancers, Lung,Cancers, Pulmonary,Lung Cancers,Lung Neoplasm,Neoplasm, Lung,Neoplasm, Pulmonary,Pulmonary Cancers,Pulmonary Neoplasm
D008647 Mesocricetus A genus in the order Rodentia and family Cricetidae. One species, Mesocricetus auratus or golden hamster is widely used in biomedical research. Hamsters, Golden,Hamsters, Golden Syrian,Hamsters, Syrian,Mesocricetus auratus,Syrian Golden Hamster,Syrian Hamster,Golden Hamster,Golden Hamster, Syrian,Golden Hamsters,Golden Syrian Hamsters,Hamster, Golden,Hamster, Syrian,Hamster, Syrian Golden,Syrian Hamsters
D009602 Nitrosamines A class of compounds that contain a -NH2 and a -NO radical. Many members of this group have carcinogenic and mutagenic properties. Nitrosamine
D006224 Cricetinae A subfamily in the family MURIDAE, comprising the hamsters. Four of the more common genera are Cricetus, CRICETULUS; MESOCRICETUS; and PHODOPUS. Cricetus,Hamsters,Hamster
D000236 Adenoma A benign epithelial tumor with a glandular organization. Adenoma, Basal Cell,Adenoma, Follicular,Adenoma, Microcystic,Adenoma, Monomorphic,Adenoma, Papillary,Adenoma, Trabecular,Adenomas,Adenomas, Basal Cell,Adenomas, Follicular,Adenomas, Microcystic,Adenomas, Monomorphic,Adenomas, Papillary,Adenomas, Trabecular,Basal Cell Adenoma,Basal Cell Adenomas,Follicular Adenoma,Follicular Adenomas,Microcystic Adenoma,Microcystic Adenomas,Monomorphic Adenoma,Monomorphic Adenomas,Papillary Adenoma,Papillary Adenomas,Trabecular Adenoma,Trabecular Adenomas
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D013329 Structure-Activity Relationship The relationship between the chemical structure of a compound and its biological or pharmacological activity. Compounds are often classed together because they have structural characteristics in common including shape, size, stereochemical arrangement, and distribution of functional groups. Relationship, Structure-Activity,Relationships, Structure-Activity,Structure Activity Relationship,Structure-Activity Relationships
D014132 Trachea The cartilaginous and membranous tube descending from the larynx and branching into the right and left main bronchi. Tracheas
D014134 Tracheal Neoplasms New abnormal growth of tissue in the TRACHEA. Neoplasm, Tracheal,Neoplasms, Tracheal,Tracheal Neoplasm

Related Publications

N Ishinishi, and A Tanaka, and A Hisanaga, and T Inamasu, and M Hirata
Comparative study on the carcinogenicity of N-nitrosodiethylamine and benzo[a]pyrene to the lung of Syrian golden hamsters induced by intermittent instillations to the trachea.
January 1985, Cancer letters,
N Ishinishi, and A Tanaka, and A Hisanaga, and T Inamasu, and M Hirata
Tumorigenicity of arsenic trioxide to the lung in Syrian golden hamsters by intermittent instillations.
December 1983, Cancer letters,
N Ishinishi, and A Tanaka, and A Hisanaga, and T Inamasu, and M Hirata
Comparative carcinogenicity of some derivatives of nitrosodi-n-propylamine in rats.
December 1978, Ecotoxicology and environmental safety,
N Ishinishi, and A Tanaka, and A Hisanaga, and T Inamasu, and M Hirata
Differential effect of chronic ethanol consumption on the carcinogenicity of N-nitrosopyrrolidine and N'-nitrosonornicotine in male Syrian golden hamsters.
July 1981, Cancer research,
N Ishinishi, and A Tanaka, and A Hisanaga, and T Inamasu, and M Hirata
Electron microscopic autoradiography of the trachea in fetal Syrian golden hamsters treated transplacentally with N-nitrosodiethylamine.
October 1982, Journal of the National Cancer Institute,
N Ishinishi, and A Tanaka, and A Hisanaga, and T Inamasu, and M Hirata
Effect of acute administration of N-nitrosopyrrolidine to male Syrian golden hamsters.
May 1994, Cancer letters,
N Ishinishi, and A Tanaka, and A Hisanaga, and T Inamasu, and M Hirata
Comparative studies with different doses of N-nitrosomorpholine, N-nitrosopiperidine, N-nitrosomethylurea, and dimethylnitrosamine in Syrian golden hamsters.
October 1973, Journal of the National Cancer Institute,
N Ishinishi, and A Tanaka, and A Hisanaga, and T Inamasu, and M Hirata
Comparative study of the toxic effects of gallium arsenide, indium arsenide and arsenic trioxide following intratracheal instillations to the lung of Syrian golden hamsters.
January 2000, Fukuoka igaku zasshi = Hukuoka acta medica,
N Ishinishi, and A Tanaka, and A Hisanaga, and T Inamasu, and M Hirata
Binding of radioactivity after transplacental administration of tritiated N-nitrosodiethylamine to Syrian golden hamsters.
February 1980, Journal of the National Cancer Institute,
N Ishinishi, and A Tanaka, and A Hisanaga, and T Inamasu, and M Hirata
Comparative carcinogenicity in F344 rats and Syrian golden hamsters of N'-nitrosonornicotine and N'-nitrosonornicotine-1-N-oxide.
October 1983, Cancer letters,
Copied contents to your clipboard!