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We determined the ranitidine dosage necessary to maintain gastric pH at or above 4 in 40 critically ill children. The patients were divided into four groups of ten patients each. They were treated with ranitidine in the following dosages: a) 2 mg/kg by NG tube every 12 h; b) 4 mg/kg by NG tube every 12 h; c) 0.75 mg/kg iv every 6 h; d) 1.5 mg/kg iv every 6 h. The fourth group had a higher median pH than the other groups, in spite of also having the highest risk of acute gastric mucosal damage (AGMD). Eight (80%) of ten patients in the fourth group had a pH greater than or equal to 4 or more than 80% of the study period. We recommend 1.5 mg/kg iv every 6 h for gastric acid inhibition in AGMD prophylaxis in children.
J Lopez-Herce Cid, and
L Albajara Velasco, and
R Codoceo, and
M A Delgado Dominguez, and
E Jimenez, and
F Ruza Tarrio
January 2019,
The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG,
J Lopez-Herce Cid, and
L Albajara Velasco, and
R Codoceo, and
M A Delgado Dominguez, and
E Jimenez, and
F Ruza Tarrio
January 1998,
Intensive care medicine,
J Lopez-Herce Cid, and
L Albajara Velasco, and
R Codoceo, and
M A Delgado Dominguez, and
E Jimenez, and
F Ruza Tarrio
January 2000,
Critical care medicine,
J Lopez-Herce Cid, and
L Albajara Velasco, and
R Codoceo, and
M A Delgado Dominguez, and
E Jimenez, and
F Ruza Tarrio
March 1986,
British journal of clinical pharmacology,
J Lopez-Herce Cid, and
L Albajara Velasco, and
R Codoceo, and
M A Delgado Dominguez, and
E Jimenez, and
F Ruza Tarrio
June 1988,
Alimentary pharmacology & therapeutics,
J Lopez-Herce Cid, and
L Albajara Velasco, and
R Codoceo, and
M A Delgado Dominguez, and
E Jimenez, and
F Ruza Tarrio
January 1981,
Acta gastroenterologica Latinoamericana,
J Lopez-Herce Cid, and
L Albajara Velasco, and
R Codoceo, and
M A Delgado Dominguez, and
E Jimenez, and
F Ruza Tarrio
August 1998,
Critical care medicine,
J Lopez-Herce Cid, and
L Albajara Velasco, and
R Codoceo, and
M A Delgado Dominguez, and
E Jimenez, and
F Ruza Tarrio
February 2011,
Wiener medizinische Wochenschrift (1946),
J Lopez-Herce Cid, and
L Albajara Velasco, and
R Codoceo, and
M A Delgado Dominguez, and
E Jimenez, and
F Ruza Tarrio
January 2008,
Critical care (London, England),
J Lopez-Herce Cid, and
L Albajara Velasco, and
R Codoceo, and
M A Delgado Dominguez, and
E Jimenez, and
F Ruza Tarrio
January 2008,
Critical care nursing quarterly,
