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The effect of spike mutations on SARS-CoV-2 neutralization. 2021
Chloe Rees-Spear, and
Luke Muir, and
Sarah A Griffith, and
Judith Heaney, and
Yoann Aldon, and
Jonne L Snitselaar, and
Peter Thomas, and
Carl Graham, and
Jeffrey Seow, and
Nayung Lee, and
Annachiara Rosa, and
Chloe Roustan, and
Catherine F Houlihan, and
Rogier W Sanders, and
Ravindra K Gupta, and
Peter Cherepanov, and
Hans J Stauss, and
Eleni Nastouli, and
, and
Katie J Doores, and
Marit J van Gils, and
Laura E McCoy
Institute of Immunity and Transplantation, Division of Infection and Immunity, University College London, London NW3 2PF, UK.
Multiple severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines show protective efficacy, which is most likely mediated by neutralizing antibodies recognizing the viral entry protein, spike. Because new SARS-CoV-2 variants are emerging rapidly, as exemplified by the B.1.1.7, B.1.351, and P.1 lineages, it is critical to understand whether antibody responses induced by infection with the original SARS-CoV-2 virus or current vaccines remain effective. In this study, we evaluate neutralization of a series of mutated spike pseudotypes based on divergence from SARS-CoV and then compare neutralization of the B.1.1.7 spike pseudotype and individual mutations. Spike-specific monoclonal antibody neutralization is reduced dramatically; in contrast, polyclonal antibodies from individuals infected in early 2020 remain active against most mutated spike pseudotypes, but potency is reduced in a minority of samples. This work highlights that changes in SARS-CoV-2 spike can alter neutralization sensitivity and underlines the need for effective real-time monitoring of emerging mutations and their effect on vaccine efficacy.
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Jeffrey Seow, and
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Hans J Stauss, and
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Katie J Doores, and
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