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The organic Ca2+ entry blockers nimodipine, verapamil, flunarizine and diltiazem belong to different chemical classes but antagonized, at the concentrations of 1 and 10 microM, the inhibitory effect exerted by 1-10 microM dopamine on in vitro prolactin secretion from the pituitary gland. The results suggest a close functional interaction between Ca2+ entry blockers and the dopamine receptors involved in the inhibition of prolactin secretion.
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