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The effects of neuropeptide Y (NPY) on the vascular tone of isolated cerebral arteries and vertebral blood flow (VBF) were studied in dogs. NPY elicited a dose-dependent contraction of arteries derived from the brain with ED50 values of 2 nM for the middle cerebral and basilar arteries. Arteries from the neck did not respond to NPY. Intra-arterial administration of NPY as a bolus reduced the VBF dose dependently, with no significant alteration of mean arterial blood pressure and heart rate. The decrease in VBF developed slowly and had a long duration, which was consistent with the observations made in vitro. NPY suppressed the contractile effect of noradrenaline (NA) on isolated cerebral arteries and pretreatment with NPY suppressed the effect of NA on VBF, indicating that NPY contributes to the inhibitory modulation of postsynaptic adrenergic mechanisms. These findings suggest that NPY could have a role in the regulation of cerebral circulation.
Y Suzuki, and
M Shibuya, and
I Ikegaki, and
S Satoh, and
M Takayasu, and
T Asano
September 1990,
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism,
Y Suzuki, and
M Shibuya, and
I Ikegaki, and
S Satoh, and
M Takayasu, and
T Asano
January 2006,
EXS,
Y Suzuki, and
M Shibuya, and
I Ikegaki, and
S Satoh, and
M Takayasu, and
T Asano
November 1989,
Journal of cardiovascular pharmacology,
Y Suzuki, and
M Shibuya, and
I Ikegaki, and
S Satoh, and
M Takayasu, and
T Asano
December 1990,
The American journal of physiology,
Y Suzuki, and
M Shibuya, and
I Ikegaki, and
S Satoh, and
M Takayasu, and
T Asano
April 1994,
European journal of pharmacology,
Y Suzuki, and
M Shibuya, and
I Ikegaki, and
S Satoh, and
M Takayasu, and
T Asano
January 1999,
Mineral and electrolyte metabolism,
Y Suzuki, and
M Shibuya, and
I Ikegaki, and
S Satoh, and
M Takayasu, and
T Asano
April 1993,
The American journal of physiology,
Y Suzuki, and
M Shibuya, and
I Ikegaki, and
S Satoh, and
M Takayasu, and
T Asano
June 1985,
Japanese circulation journal,
Y Suzuki, and
M Shibuya, and
I Ikegaki, and
S Satoh, and
M Takayasu, and
T Asano
March 1992,
Brain research,
Y Suzuki, and
M Shibuya, and
I Ikegaki, and
S Satoh, and
M Takayasu, and
T Asano
April 1993,
Sheng li ke xue jin zhan [Progress in physiology],
