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[Hepatitis probably caused by Plethoryl. Apropos of 7 cases]. 1988
D Larrey, and
E Fréneaux, and
G Babany, and
A Berson, and
O Amédée-Manesme, and
C Degott, and
L Bettan, and
B Paugam, and
D Pessayre, and
J P Benhamou
Unité de Recherches de Physiopathologie Hépatique (INSERM U 24), Hôpital Beaujon, Clichy.
Seven patients developed acute hepatitis after receiving Plethoryl for obesity for 4 to 16 weeks. Jaundice was generally associated with or preceded by asthenia, nausea and pruritus. Serum aminotransferase activities were markedly increased whereas alkaline phosphatase and gamma-glutamyltransferase activities were moderately elevated. There was no hepatic failure. In all cases, Plethoryl administration was promptly discontinued. In 6 cases, jaundice disappeared within 2 to 4 weeks, and recovery occurred within 2 to 5 months. In one case, however, jaundice disappeared within 12 weeks and recovery took 10 months.
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