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Chronic hyperprolactinemia was obtained in the rat by an implantation of two adenohypophyses under the kidney capsule. This experimental model was set to evaluate the influence that high prolactin levels may have on bone mineralization when an intervention of estrogens can reasonably be excluded. Bone density was measured by single photon absorptiometry at the femur level. Our results indicate that the increase in PRL throughout the period of observation was associated with a significant decrease in bone mineral content, while calcium and parathyroid hormone serum levels remained unchanged. This would suggest that PRL plays a role in bone calcium metabolism, that might be included among the effects of this hormone.
C E Fiore, and
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R Foti, and
G Conforto
June 1988,
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C E Fiore, and
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G Conforto
January 1981,
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R Foti, and
G Conforto
July 1993,
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C E Fiore, and
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C E Fiore, and
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G Conforto
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C E Fiore, and
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G Conforto
January 1977,
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C E Fiore, and
G Clementi, and
A Prato, and
R Foti, and
G Conforto
May 1986,
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C E Fiore, and
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G Conforto
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C E Fiore, and
G Clementi, and
A Prato, and
R Foti, and
G Conforto
November 1991,
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C E Fiore, and
G Clementi, and
A Prato, and
R Foti, and
G Conforto
July 1988,
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