BACKGROUND The magnitude of postpartum depression in Jordan is under documented, and little is known about its potential sociodemographic and clinical correlates. OBJECTIVE The aim of this study was to explore the prevalence and risk factors associated with postpartum depression among Jordanian mothers in the first 18 months after delivery. METHODS This descriptive cross-sectional study was carried out from April to June 2020 in Jordan. A web-based survey was used for recruiting eligible participants. An Arabic version of the validated self-administered Edinburgh Postnatal Depression Scale questionnaire was used to measure postpartum depression with a cut-off score of ⩾12 which indicates probable depression. RESULTS A total of 1,071 Jordanian women participated in the study. Of those, 567 women had postpartum depression (52.9%). Multivariate logistic regression analysis revealed that postpartum depression was significantly associated with marital conflict (OR: 4.91; 95% CI: 2.36-10.20), negative attitude from the pregnancy (OR: 0.67; 95% CI: 0.45-0.99), unplanned pregnancies (OR: 1.73; 95% CI: 1.16-2.60), lack of social support (OR: 1.93; 95% CI: 1.12-3.32), time from last delivery (OR: 0.99; 95% CI: 0.98-1.00), insomnia (OR: 0.53; 95% CI: 0.35-0.82), and depression during the pregnancy (OR: 0.51; 95% CI: 0.33-0.78). Most of the participants (65.7%) sought social support to avoid, reduce, or treat postpartum depression. CONCLUSIONS Postpartum depression among Jordanian women was the highest in comparison to that of women in other countries in the region. Therefore, screening for the presence of depressive symptoms should be implemented during regular pregnancy care visits. Social support should be encouraged in order to avoid, reduce, or treat postpartum depression.