Nicotine withdrawal induces hyperalgesia via downregulation of descending serotonergic pathway in the nucleus raphe magnus. 2021

Ling Shen, and Hai-Bo Qiu, and Hui-Hong Xu, and Kai Wei, and Liang Zhao, and Cheng-Cheng Zhu, and Cheng-Jian Li, and Zhi-Jie Lu
Department of Anesthesiology, Shanghai Eastern Hepatobiliary Surgery Hospital, Shanghai, 200438, China.

Patients deprived of cigarettes exhibit increased pain sensitivity during perioperative periods, yet the underlying neuroanatomical and molecular bases of this hypersensitivity are unclear. The present study showed that both the mechanical withdrawal threshold (MWT) and thermal withdrawal latency (TWL) were significantly decreased in a rat model of nicotine withdrawal. These rats showed less tryptophan hydroxylase 2 (TPH2) positive neurons and reduced TPH2 expression in the nucleus raphe magnus (NRM), and thus resulted in decreased 5-hydroxytryptamine (5-HT) levels in cerebrospinal fluid. Intrathecal injection of 5-HT or NRM microinjection of TPH-overexpression adeno-associated virus alleviated nicotine withdrawal-induced hyperalgesia, whereas 5-HT receptor pharmacological blockade by methysergide (a 5-HT receptor antagonist) exacerbated hypersensitivity and diminished the difference between the two groups. Together, these data indicate that hyperalgesia after nicotine withdrawal is mediated by declined descending serotonergic pathways in the NRM. This provides a new perspective to improve the postoperative pain management of patients, especially the smokers.

UI MeSH Term Description Entries
D007278 Injections, Spinal Introduction of therapeutic agents into the spinal region using a needle and syringe. Injections, Intraspinal,Injections, Intrathecal,Intraspinal Injections,Intrathecal Injections,Spinal Injections,Injection, Intraspinal,Injection, Intrathecal,Injection, Spinal,Intraspinal Injection,Intrathecal Injection,Spinal Injection
D007279 Injections, Subcutaneous Forceful administration under the skin of liquid medication, nutrient, or other fluid through a hollow needle piercing the skin. Subcutaneous Injections,Injection, Subcutaneous,Subcutaneous Injection
D008297 Male Males
D009538 Nicotine Nicotine is highly toxic alkaloid. It is the prototypical agonist at nicotinic cholinergic receptors where it dramatically stimulates neurons and ultimately blocks synaptic transmission. Nicotine is also important medically because of its presence in tobacco smoke. Nicotine Bitartrate,Nicotine Tartrate
D011985 Receptors, Serotonin Cell-surface proteins that bind SEROTONIN and trigger intracellular changes which influence the behavior of cells. Several types of serotonin receptors have been recognized which differ in their pharmacology, molecular biology, and mode of action. 5-HT Receptor,5-HT Receptors,5-Hydroxytryptamine Receptor,5-Hydroxytryptamine Receptors,Receptors, Tryptamine,Serotonin Receptor,Serotonin Receptors,Tryptamine Receptor,Tryptamine Receptors,Receptors, 5-HT,Receptors, 5-Hydroxytryptamine,5 HT Receptor,5 HT Receptors,5 Hydroxytryptamine Receptor,5 Hydroxytryptamine Receptors,Receptor, 5-HT,Receptor, 5-Hydroxytryptamine,Receptor, Serotonin,Receptor, Tryptamine,Receptors, 5 HT,Receptors, 5 Hydroxytryptamine
D006930 Hyperalgesia An increased sensation of pain or discomfort produced by minimally noxious stimuli due to damage to soft tissue containing NOCICEPTORS or injury to a peripheral nerve. Hyperalgesia, Tactile,Hyperalgesia, Thermal,Hyperalgia,Hyperalgia, Mechanical,Hyperalgia, Primary,Hyperalgia, Secondary,Allodynia,Allodynia, Mechanical,Allodynia, Tactile,Allodynia, Thermal,Hyperalgesia, Mechanical,Hyperalgesia, Primary,Hyperalgesia, Secondary,Hyperalgesic Sensations,Mechanical Allodynia,Mechanical Hyperalgesia,Tactile Allodynia,Thermal Allodynia,Allodynias,Hyperalgesias,Hyperalgesias, Thermal,Hyperalgesic Sensation,Mechanical Hyperalgia,Mechanical Hyperalgias,Primary Hyperalgia,Primary Hyperalgias,Secondary Hyperalgia,Secondary Hyperalgias,Sensation, Hyperalgesic,Sensations, Hyperalgesic,Thermal Hyperalgesia
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D012701 Serotonin A biochemical messenger and regulator, synthesized from the essential amino acid L-TRYPTOPHAN. In humans it is found primarily in the central nervous system, gastrointestinal tract, and blood platelets. Serotonin mediates several important physiological functions including neurotransmission, gastrointestinal motility, hemostasis, and cardiovascular integrity. Multiple receptor families (RECEPTORS, SEROTONIN) explain the broad physiological actions and distribution of this biochemical mediator. 5-HT,5-Hydroxytryptamine,3-(2-Aminoethyl)-1H-indol-5-ol,Enteramine,Hippophaine,Hydroxytryptamine,5 Hydroxytryptamine
D013375 Substance Withdrawal Syndrome Physiological and psychological symptoms associated with withdrawal from the use of a drug after prolonged administration or habituation. The concept includes withdrawal from smoking or drinking, as well as withdrawal from an administered drug. Drug Withdrawal Symptoms,Withdrawal Symptoms,Drug Withdrawal Symptom,Substance Withdrawal Syndromes,Symptom, Drug Withdrawal,Symptom, Withdrawal,Symptoms, Drug Withdrawal,Symptoms, Withdrawal,Syndrome, Substance Withdrawal,Syndromes, Substance Withdrawal,Withdrawal Symptom,Withdrawal Symptom, Drug,Withdrawal Symptoms, Drug,Withdrawal Syndrome, Substance,Withdrawal Syndromes, Substance
D015536 Down-Regulation A negative regulatory effect on physiological processes at the molecular, cellular, or systemic level. At the molecular level, the major regulatory sites include membrane receptors, genes (GENE EXPRESSION REGULATION), mRNAs (RNA, MESSENGER), and proteins. Receptor Down-Regulation,Down-Regulation (Physiology),Downregulation,Down Regulation,Down-Regulation, Receptor

Related Publications

Ling Shen, and Hai-Bo Qiu, and Hui-Hong Xu, and Kai Wei, and Liang Zhao, and Cheng-Cheng Zhu, and Cheng-Jian Li, and Zhi-Jie Lu
February 2024, European journal of pain (London, England),
Ling Shen, and Hai-Bo Qiu, and Hui-Hong Xu, and Kai Wei, and Liang Zhao, and Cheng-Cheng Zhu, and Cheng-Jian Li, and Zhi-Jie Lu
January 1986, Scientia Sinica. Series B, Chemical, biological, agricultural, medical & earth sciences,
Ling Shen, and Hai-Bo Qiu, and Hui-Hong Xu, and Kai Wei, and Liang Zhao, and Cheng-Cheng Zhu, and Cheng-Jian Li, and Zhi-Jie Lu
January 1987, Masui. The Japanese journal of anesthesiology,
Ling Shen, and Hai-Bo Qiu, and Hui-Hong Xu, and Kai Wei, and Liang Zhao, and Cheng-Cheng Zhu, and Cheng-Jian Li, and Zhi-Jie Lu
June 1981, Brain research,
Ling Shen, and Hai-Bo Qiu, and Hui-Hong Xu, and Kai Wei, and Liang Zhao, and Cheng-Cheng Zhu, and Cheng-Jian Li, and Zhi-Jie Lu
July 2009, Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova,
Ling Shen, and Hai-Bo Qiu, and Hui-Hong Xu, and Kai Wei, and Liang Zhao, and Cheng-Cheng Zhu, and Cheng-Jian Li, and Zhi-Jie Lu
February 1981, Brain research,
Ling Shen, and Hai-Bo Qiu, and Hui-Hong Xu, and Kai Wei, and Liang Zhao, and Cheng-Cheng Zhu, and Cheng-Jian Li, and Zhi-Jie Lu
June 1985, Brain research,
Ling Shen, and Hai-Bo Qiu, and Hui-Hong Xu, and Kai Wei, and Liang Zhao, and Cheng-Cheng Zhu, and Cheng-Jian Li, and Zhi-Jie Lu
February 1986, Neuroscience research,
Ling Shen, and Hai-Bo Qiu, and Hui-Hong Xu, and Kai Wei, and Liang Zhao, and Cheng-Cheng Zhu, and Cheng-Jian Li, and Zhi-Jie Lu
April 1991, The Journal of pharmacology and experimental therapeutics,
Ling Shen, and Hai-Bo Qiu, and Hui-Hong Xu, and Kai Wei, and Liang Zhao, and Cheng-Cheng Zhu, and Cheng-Jian Li, and Zhi-Jie Lu
March 1986, Pain,
Copied contents to your clipboard!