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An automated liquid chromatographic method for the determination of urinary concentrations of 4-hydroxy-3-methoxymandelic acid (VMA) is described. Urine samples are purified by solid-phase extraction on an anion-exchange cartridge and automated on-line chromatographic elution is carried out using a Varian AASP (advanced automated sample processor) system. The column effluent is monitored with an electrochemical detector using a glassy carbon working electrode. The method allows the determination of VMA in 0.05 ml of normal urine with a relative standard deviation of less than 3%. The analysis time can be shortened by use of back-flushing technique, and the correlation with a classical (but non-automated) VMA analysis method is excellent.
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F Guyon, and
M Caude, and
R Rosset
December 1979,
Clinical chemistry,
P Ni, and
F Guyon, and
M Caude, and
R Rosset
May 1983,
Clinical chemistry,
P Ni, and
F Guyon, and
M Caude, and
R Rosset
December 1993,
Clinical chemistry,
P Ni, and
F Guyon, and
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R Rosset
May 1983,
Clinical chemistry,
P Ni, and
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R Rosset
July 1986,
Rinsho byori. The Japanese journal of clinical pathology,
P Ni, and
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P Ni, and
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December 1985,
Clinica chimica acta; international journal of clinical chemistry,
P Ni, and
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March 1981,
Medical laboratory sciences,
P Ni, and
F Guyon, and
M Caude, and
R Rosset
December 1984,
Journal of chromatography,
P Ni, and
F Guyon, and
M Caude, and
R Rosset
June 1984,
Life sciences,
