Phytochemistry and teratogenic potential of Mimosa tenuiflora (willd.) poir. (Fabaceae) in ruminants: A systematic review. 2021

José Jailson Lima Bezerra, and Anderson Angel Vieira Pinheiro, and Ricardo Barbosa Lucena
Universidade Federal de Pernambuco, Departamento de Botânica, Av. da Engenharia, S/n, Cidade Universitária, 50670-420, Recife, PE, Brazil.

Mimosa tenuiflora (Willd.) Poir. (Fabaceae) is a plant native to Brazil and occurs in the phytogeographic domains of Caatinga and Cerrado. Relevant studies have investigated the chemical components of this plant and others have already demonstrated its teratogenic potential. It has been proven that this plant causes congenital malformations in farm animals and, consequently, financial losses to farmers in the Brazilian semiarid region. The present work aimed to carry out a bibliographic survey on the teratogenic effects of M. tenuiflora in ruminants and to group the chemical compounds occurring in this species. For this, databases were consulted and twenty-four articles published in the last 30 years (1990-2020) were included. According to the scientific documents analyzed, M. tenuiflora has embryotoxic, fetotoxic and abortive potential in farm animals, especially sheep and goats. The main classes of chemical compounds present in this species are alkaloids, saponins, flavonoids, and terpenoids. It is likely that some of these substances, mainly the indole alkaloid N,N-dimethyltryptamine, are related to the teratogenic effects reported in ruminants in the Brazilian semiarid region.

UI MeSH Term Description Entries
D007887 Fabaceae The large family of plants characterized by pods. Some are edible and some cause LATHYRISM or FAVISM and other forms of poisoning. Other species yield useful materials like gums from ACACIA and various LECTINS like PHYTOHEMAGGLUTININS from PHASEOLUS. Many of them harbor NITROGEN FIXATION bacteria on their roots. Many but not all species of "beans" belong to this family. Afzelia,Amorpha,Andira,Baptisia,Callerya,Ceratonia,Clathrotropis,Colophospermum,Copaifera,Delonix,Euchresta,Guibourtia,Legumes,Machaerium,Pithecolobium,Stryphnodendron,Leguminosae,Pea Family,Pithecellobium,Tachigalia,Families, Pea,Family, Pea,Legume,Pea Families
D010939 Plant Poisoning Poisoning by the ingestion of plants or its leaves, berries, roots or stalks. The manifestations in both humans and animals vary in severity from mild to life threatening. In animals, especially domestic animals, it is usually the result of ingesting moldy or fermented forage. Poisoning, Plant,Plant Poisonings,Poisonings, Plant
D001938 Brazil A country located on the eastern coast of South America, located between Colombia and Peru, that borders the Atlantic Ocean. It is bordered on the north by Venezuela, Guyana, Suriname, and French Guiana, on the south by Uruguay, and on the west by Argentina. The capital is Brasilia.
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D012418 Ruminants A suborder of the order ARTIODACTYLA whose members have the distinguishing feature of a four-chambered stomach, including the capacious RUMEN. Horns or antlers are usually present, at least in males. Goats, Mountain,Ruminantia,Oreamnos americanus,Goat, Mountain,Mountain Goat,Mountain Goats,Ruminant
D012756 Sheep Any of the ruminant mammals with curved horns in the genus Ovis, family Bovidae. They possess lachrymal grooves and interdigital glands, which are absent in GOATS. Ovis,Sheep, Dall,Dall Sheep,Ovis dalli
D013723 Teratogens An agent that causes the production of physical defects in the developing embryo. Embryotoxins,Fetotoxins,Teratogen
D031298 Mimosa A plant genus of the family FABACEAE that contains kukulkanin, a CHALCONE. Mimosas

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