BIOMAT Database Logo BIOMAT Database Logo

3,5-Dimethoxy-4-hydroxy myricanol attenuated oxidative stress-induced toxicity on cardiomyoblast cells. 2021

Y L Wang, and Y Zhang, and T Liu, and J Cui
Department of Cardiology, The Second Hospital of Hebei Medical University, Shijiazhuang, China.

Myocardial ischemia is the main reason for ischemic heart diseases. Antioxidant treatment is considered as a possible approach to prevent myocardial ischemia injury, because oxidative stress is a key factor triggering it. This study was to investigate the protective effects of 3,5-dimethoxy-4-hydroxy myricanol (DHM) against oxidative stress-induced cytotoxicity on H9c2 cells and further explore its mechanisms. The oxidative stress and inflammatory response markers were detected by H2DCFDA fluorescent measurement, enzyme-linked immunosorbent assay (ELISA), real-time PCR and Western blot. Results showed DHM exerted inhibitory effects against H9c2 cell damage. Furthermore, DHM decreased oxidative stress in H9c2 cells through up-regulating protein expression of heme oxygenase-1 (HO-1) and nuclear factor (erythroid-derived 2)-like 2 (Nrf2). Moreover, DHM inhibited inflammatory responses through down-regulating the protein expression of mitogen-activated protein kinases (MAPKs) and nuclear factor kappa B (NF-κB). DHM exerted protective activities against oxidative stress-induced cell damage, at least through decreasing oxidative stress and inhibiting inflammatory responses, indicating that DHM have the potential to be developed as therapeutic agents for the treatment of myocardial ischemia.

UI MeSH Term Description Entries
D002470 Cell Survival The span of viability of a cell characterized by the capacity to perform certain functions such as metabolism, growth, reproduction, some form of responsiveness, and adaptability. Cell Viability,Cell Viabilities,Survival, Cell,Viabilities, Cell,Viability, Cell
D002478 Cells, Cultured Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others. Cultured Cells,Cell, Cultured,Cultured Cell
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D017202 Myocardial Ischemia A disorder of cardiac function caused by insufficient blood flow to the muscle tissue of the heart. The decreased blood flow may be due to narrowing of the coronary arteries (CORONARY ARTERY DISEASE), to obstruction by a thrombus (CORONARY THROMBOSIS), or less commonly, to diffuse narrowing of arterioles and other small vessels within the heart. Severe interruption of the blood supply to the myocardial tissue may result in necrosis of cardiac muscle (MYOCARDIAL INFARCTION). Heart Disease, Ischemic,Ischemia, Myocardial,Ischemic Heart Disease,Disease, Ischemic Heart,Diseases, Ischemic Heart,Heart Diseases, Ischemic,Ischemias, Myocardial,Ischemic Heart Diseases,Myocardial Ischemias
D017209 Apoptosis A regulated cell death mechanism characterized by distinctive morphologic changes in the nucleus and cytoplasm, including the endonucleolytic cleavage of genomic DNA, at regularly spaced, internucleosomal sites, i.e., DNA FRAGMENTATION. It is genetically programmed and serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth. Apoptosis, Extrinsic Pathway,Apoptosis, Intrinsic Pathway,Caspase-Dependent Apoptosis,Classic Apoptosis,Classical Apoptosis,Programmed Cell Death,Programmed Cell Death, Type I,Apoptoses, Extrinsic Pathway,Apoptoses, Intrinsic Pathway,Apoptosis, Caspase-Dependent,Apoptosis, Classic,Apoptosis, Classical,Caspase Dependent Apoptosis,Cell Death, Programmed,Classic Apoptoses,Extrinsic Pathway Apoptoses,Extrinsic Pathway Apoptosis,Intrinsic Pathway Apoptoses,Intrinsic Pathway Apoptosis
D018384 Oxidative Stress A disturbance in the prooxidant-antioxidant balance in favor of the former, leading to potential damage. Indicators of oxidative stress include damaged DNA bases, protein oxidation products, and lipid peroxidation products (Sies, Oxidative Stress, 1991, pxv-xvi). Anti-oxidative Stress,Antioxidative Stress,DNA Oxidative Damage,Nitro-Oxidative Stress,Oxidative Cleavage,Oxidative DNA Damage,Oxidative Damage,Oxidative Injury,Oxidative Nitrative Stress,Oxidative Stress Injury,Oxidative and Nitrosative Stress,Stress, Oxidative,Anti oxidative Stress,Anti-oxidative Stresses,Antioxidative Stresses,Cleavage, Oxidative,DNA Damage, Oxidative,DNA Oxidative Damages,Damage, DNA Oxidative,Damage, Oxidative,Damage, Oxidative DNA,Injury, Oxidative,Injury, Oxidative Stress,Nitrative Stress, Oxidative,Nitro Oxidative Stress,Nitro-Oxidative Stresses,Oxidative Cleavages,Oxidative DNA Damages,Oxidative Damage, DNA,Oxidative Damages,Oxidative Injuries,Oxidative Nitrative Stresses,Oxidative Stress Injuries,Oxidative Stresses,Stress Injury, Oxidative,Stress, Anti-oxidative,Stress, Antioxidative,Stress, Nitro-Oxidative,Stress, Oxidative Nitrative,Stresses, Nitro-Oxidative
D020011 Protective Agents Synthetic or natural substances which are given to prevent a disease or disorder or are used in the process of treating a disease or injury due to a poisonous agent. Protective Agent,Protective Drug,Protective Drugs,Agent, Protective,Agents, Protective,Drug, Protective,Drugs, Protective
D032386 Myoblasts, Cardiac Precursor cells destined to differentiate into cardiac myocytes (MYOCYTES, CARDIAC). Cardiac Myoblast,Cardiac Myoblasts,Myoblast, Cardiac
D036381 Diarylheptanoids A group of compounds consisting of two aryl rings linked by seven carbons (HEPTANES) which may be acyclic (linear) or cyclic. It is a group of secondary metabolites in polyketide synthesis pathway best exemplified by a linear diarylheptanoid CURCUMIN. Acyclic Diarylheptanoids,Curcuminoid,Curcuminoids,Cyclic Diarylheptanoid,Cyclic Diarylheptanoids,Diaryl Heptanoids,Diarylheptanoid,Diarylheptanoid Derivative,Diarylheptanoid Derivatives,Linear Diarylheptanoids,Diarylheptanones,Derivative, Diarylheptanoid,Diarylheptanoid, Cyclic,Diarylheptanoids, Acyclic,Diarylheptanoids, Cyclic,Diarylheptanoids, Linear,Heptanoids, Diaryl

Related Publications

Y L Wang, and Y Zhang, and T Liu, and J Cui
3,5-Dimethoxy-4-hydroxy myricanol ameliorates photoreceptor cell degeneration in Pde6brd10 mouse model.
March 2019, Cutaneous and ocular toxicology,
Y L Wang, and Y Zhang, and T Liu, and J Cui
(Z)-7,4'-dimethoxy-6-hydroxy-aurone-4-O-β-glucopyranoside attenuates lipoteichoic acid-induced damage in rat cardiomyoblast cells.
August 2020, The Journal of international medical research,
Y L Wang, and Y Zhang, and T Liu, and J Cui
Eicosapentaenoic acid attenuated oxidative stress-induced cardiomyoblast apoptosis by activating adaptive autophagy.
January 2014, European journal of nutrition,
Y L Wang, and Y Zhang, and T Liu, and J Cui
Encapsulation of 4-hydroxy-3-methoxy benzoic acid and 4-hydroxy-3,5-dimethoxy benzoic acid with native and modified cyclodextrins.
February 2015, Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy,
Y L Wang, and Y Zhang, and T Liu, and J Cui
Benomyl induced oxidative stress related DNA damage and apoptosis in H9c2 cardiomyoblast cells.
September 2021, Toxicology in vitro : an international journal published in association with BIBRA,
Y L Wang, and Y Zhang, and T Liu, and J Cui
3,5-Dimethoxy-(4-methoxyphenyl)benzamide suppresses adipogenesis in 3T3-L1 cells.
January 2014, Acta poloniae pharmaceutica,
Y L Wang, and Y Zhang, and T Liu, and J Cui
Resveratrol attenuates 4-hydroxy-2-hexenal-induced oxidative stress in mouse cortical collecting duct cells.
May 2016, The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology,
Y L Wang, and Y Zhang, and T Liu, and J Cui
Capparis spinosa reduces Doxorubicin-induced cardio-toxicity in cardiomyoblast cells.
January 2016, Avicenna journal of phytomedicine,
Y L Wang, and Y Zhang, and T Liu, and J Cui
Anti-sickling, analgesic and anti-inflammatory properties of 3,5-dimethoxy-4-hydroxy benzoic acid and 2,3,4-trihydroxyacetophenone.
April 2000, Phytomedicine : international journal of phytotherapy and phytopharmacology,
Y L Wang, and Y Zhang, and T Liu, and J Cui
1-(4-Hydr-oxy-3,5-dimethoxy-phen-yl)ethanone.
November 2009, Acta crystallographica. Section E, Structure reports online,
Copied contents to your clipboard!