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Temporal Trends, Characteristics, and Outcomes of Infective Endocarditis After Transcatheter Aortic Valve Replacement. 2021
David Del Val, and
Mohamed Abdel-Wahab, and
Axel Linke, and
Eric Durand, and
Nikolaj Ihlemann, and
Marina Urena, and
Costanza Pellegrini, and
Francesco Giannini, and
Martin Landt, and
Vincent Auffret, and
Jan Malte Sinning, and
Asim Cheema, and
Luis Nombela-Franco, and
Chekrallah Chamandi, and
Francisco Campelo-Parada, and
Antonio Munoz-Garcia, and
Howard C Herrmann, and
Luca Testa, and
Kim Won-Keun, and
Juan Carlos Castillo, and
Alberto Alperi, and
Didier Tchetche, and
Antonio Bartorelli, and
Samir Kapadia, and
Stefan Stortecky, and
Ignacio Amat-Santos, and
Harindra C Wijeysundera, and
John Lisko, and
Enrique Gutiérrez-Ibanes, and
Vicenç Serra, and
Luisa Salido, and
Abdullah Alkhodair, and
Ugolino Livi, and
Tarun Chakravarty, and
Stamatios Lerakis, and
Victoria Vilalta, and
Ander Regueiro, and
Rafael Romaguera, and
Marco Barbanti, and
Jean-Bernard Masson, and
Frédéric Maes, and
Claudia Fiorina, and
Antonio Miceli, and
Susheel Kodali, and
Henrique B Ribeiro, and
Jose Armando Mangione, and
Fabio Sandoli de Brito, and
Guglielmo Mario Actis Dato, and
Francesco Rosato, and
Maria-Cristina Ferreira, and
Valter Correa Lima, and
Alexandre Siciliano Colafranceschi, and
Alexandre Abizaid, and
Marcos Antonio Marino, and
Vinicius Esteves, and
Julio Andrea, and
Roger R Godinho, and
Helene Eltchaninoff, and
Lars Søndergaard, and
Dominique Himbert, and
Oliver Husser, and
Azeem Latib, and
Hervé Le Breton, and
Clement Servoz, and
Isaac Pascual, and
Saif Siddiqui, and
Paolo Olivares, and
Rosana Hernandez-Antolin, and
John G Webb, and
Sandro Sponga, and
Raj Makkar, and
Annapoorna S Kini, and
Marouane Boukhris, and
Norman Mangner, and
Lisa Crusius, and
David Holzhey, and
Josep Rodés-Cabau
Quebec Heart and Lung Institute, Laval University, Quebec City, Canada.
Procedural improvements combined with the contemporary clinical profile of patients undergoing transcatheter aortic valve replacement (TAVR) may have influenced the incidence and outcomes of infective endocarditis (IE) following TAVR. We aimed to determine the temporal trends, characteristics, and outcomes of IE post-TAVR. Observational study including 552 patients presenting definite IE post-TAVR. Patients were divided in 2 groups according to the timing of TAVR (historical cohort [HC]: before 2014; contemporary cohort [CC]: after 2014). Overall incidence rates of IE were similar in both cohorts (CC vs HC: 5.45 vs 6.52 per 1000 person-years; P = .12), but the rate of early IE was lower in the CC (2.29‰ vs 4.89‰, P < .001). Enterococci were the most frequent microorganism. Most patients presented complicated IE ( CC: 67.7%; HC: 69.6%; P = .66), but the rate of surgical treatment remained low (CC: 20.7%; HC: 17.3%; P = .32). The CC exhibited lower rates of in-hospital acute kidney injury (35.1% vs 44.6%; P = .036) and in-hospital (26.6% vs 36.4%; P = .016) and 1-year (37.8% vs 53.5%; P < .001) mortality. Higher logistic EuroScore, Staphylococcus aureus etiology, and complications (stroke, heart failure, and acute renal failure) were associated with in-hospital mortality in multivariable analyses (P < .05 for all). Although overall IE incidence has remained stable, the incidence of early IE has declined in recent years. The microorganism, high rate of complications, and very low rate of surgical treatment remained similar. In-hospital and 1-year mortality rates were high but progressively decreased over time.
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Kim Won-Keun, and
Juan Carlos Castillo, and
Alberto Alperi, and
Didier Tchetche, and
Antonio Bartorelli, and
Samir Kapadia, and
Stefan Stortecky, and
Ignacio Amat-Santos, and
Harindra C Wijeysundera, and
John Lisko, and
Enrique Gutiérrez-Ibanes, and
Vicenç Serra, and
Luisa Salido, and
Abdullah Alkhodair, and
Ugolino Livi, and
Tarun Chakravarty, and
Stamatios Lerakis, and
Victoria Vilalta, and
Ander Regueiro, and
Rafael Romaguera, and
Marco Barbanti, and
Jean-Bernard Masson, and
Frédéric Maes, and
Claudia Fiorina, and
Antonio Miceli, and
Susheel Kodali, and
Henrique B Ribeiro, and
Jose Armando Mangione, and
Fabio Sandoli de Brito, and
Guglielmo Mario Actis Dato, and
Francesco Rosato, and
Maria-Cristina Ferreira, and
Valter Correa Lima, and
Alexandre Siciliano Colafranceschi, and
Alexandre Abizaid, and
Marcos Antonio Marino, and
Vinicius Esteves, and
Julio Andrea, and
Roger R Godinho, and
Helene Eltchaninoff, and
Lars Søndergaard, and
Dominique Himbert, and
Oliver Husser, and
Azeem Latib, and
Hervé Le Breton, and
Clement Servoz, and
Isaac Pascual, and
Saif Siddiqui, and
Paolo Olivares, and
Rosana Hernandez-Antolin, and
John G Webb, and
Sandro Sponga, and
Raj Makkar, and
Annapoorna S Kini, and
Marouane Boukhris, and
Norman Mangner, and
Lisa Crusius, and
David Holzhey, and
Josep Rodés-Cabau
April 2024,
Cardiovascular revascularization medicine : including molecular interventions,
