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A pharmacokinetic study on ceftriaxone (CTRX) was conducted and the results obtained are summarized as follows. 1. CTRX was given in a dose of 20 micrograms/kg by intravenous bolus injection to 13 neonates, and satisfactory blood concentrations of the drug were achieved. However, since even a once daily administration revealed trough values of 10-20 micrograms/ml, CTRX may accumulate if administered to neonates of low weight. 2. The rate of CTRX transfer to cerebrospinal fluid was 5.7% in a neonate given a dose of 20 mg/kg by intravenous bolus injection. 3. The urinary recovery rate was 8.4% up to 12 hours in a neonate given a dose of 20 mg/kg by intravenous bolus injection.
K Sunakawa, and
Y Sato
September 1988,
The Japanese journal of antibiotics,
K Sunakawa, and
Y Sato
September 1984,
The Journal of pediatrics,
K Sunakawa, and
Y Sato
March 1988,
The Japanese journal of antibiotics,
K Sunakawa, and
Y Sato
October 2023,
European journal of pediatrics,
K Sunakawa, and
Y Sato
February 1988,
The Japanese journal of antibiotics,
K Sunakawa, and
Y Sato
September 1991,
Hospital practice (Office ed.),
K Sunakawa, and
Y Sato
January 1993,
Pharmacotherapy,
K Sunakawa, and
Y Sato
March 1988,
The Japanese journal of antibiotics,
K Sunakawa, and
Y Sato
November 1981,
Antimicrobial agents and chemotherapy,
K Sunakawa, and
Y Sato
June 1987,
Pathologie-biologie,
