Standard photopatch test battery? Proposal based on current epidemiology and experience in our Skin Allergy Unit. 2021

Rubén García Castro, and Virginia Velasco Tirado, and Montserrat Alonso Sardón, and Marta González de Arriba
Dermatology Department, Hospital Clínico de Salamanca, Salamanca, Spain.

BACKGROUND The diagnosis of photoallergic contact dermatitis (PACD) is confirmed by photopatch testing (PPT). In Spain, the latest recommendation on which allergens to test in PPT dates from 1995. METHODS In the last 4 years, we studied 455 patients with epicutaneous tests and performed PPT on 33 of those patients (7.3%). RESULTS The most prevalent allergens in PPT were as follows: non-steroidal anti-inflammatory drugs (NSAIDs) (46%), fragrances (21%), and solar filters (18%). CONCLUSIONS In our country, the most common photoallergens continue to be NSAIDs (ketoprofen). The increasingly common use of sunscreens has led to a growing involvement of solar filters in PACD, which can be also contained in other cosmetics. In our experience, PACD due to fragrances is nonetheless at least similar in frequency. CONCLUSIONS The PPT battery must adapt to the prescription, use, and exposure habits of each country. We propose a diagnostic model to guide which allergens to test in PPT, which in our experience should also include fragrances.

UI MeSH Term Description Entries
D010328 Patch Tests Skin tests in which the sensitizer is applied to a patch of cotton cloth or gauze held in place for approximately 48-72 hours. It is used for the elicitation of a contact hypersensitivity reaction. Patch Testing,Patch Test,Patch Testings,Test, Patch,Testing, Patch,Testings, Patch,Tests, Patch
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000485 Allergens Antigen-type substances that produce immediate hypersensitivity (HYPERSENSITIVITY, IMMEDIATE). Allergen
D013473 Sunscreening Agents Chemical or physical agents that protect the skin from sunburn and erythema by absorbing or blocking ultraviolet radiation. Sunscreen,Sunscreens,Agents, Sunscreening
D014466 Ultraviolet Rays That portion of the electromagnetic spectrum immediately below the visible range and extending into the x-ray frequencies. The longer wavelengths (near-UV or biotic or vital rays) are necessary for the endogenous synthesis of vitamin D and are also called antirachitic rays; the shorter, ionizing wavelengths (far-UV or abiotic or extravital rays) are viricidal, bactericidal, mutagenic, and carcinogenic and are used as disinfectants. Actinic Rays,Black Light, Ultraviolet,UV Light,UV Radiation,Ultra-Violet Rays,Ultraviolet Light,Ultraviolet Radiation,Actinic Ray,Light, UV,Light, Ultraviolet,Radiation, UV,Radiation, Ultraviolet,Ray, Actinic,Ray, Ultra-Violet,Ray, Ultraviolet,Ultra Violet Rays,Ultra-Violet Ray,Ultraviolet Black Light,Ultraviolet Black Lights,Ultraviolet Radiations,Ultraviolet Ray
D017454 Dermatitis, Photoallergic A delayed hypersensitivity involving the reaction between sunlight or other radiant energy source and a chemical substance to which the individual has been previously exposed and sensitized. It manifests as a papulovesicular, eczematous, or exudative dermatitis occurring chiefly on the light-exposed areas of the skin. Dermatitis, Contact, Photoallergic,Dermatitis, Contact, Photosensitive,Dermatitis, Photocontact,Photoallergy,Photoallergic Contact Dermatitis,Photosensitive Contact Dermatitis,Contact Dermatitides, Photoallergic,Contact Dermatitides, Photosensitive,Contact Dermatitis, Photoallergic,Contact Dermatitis, Photosensitive,Dermatitides, Photoallergic,Dermatitides, Photoallergic Contact,Dermatitides, Photocontact,Dermatitides, Photosensitive Contact,Dermatitis, Photoallergic Contact,Dermatitis, Photosensitive Contact,Photoallergic Contact Dermatitides,Photoallergic Dermatitides,Photoallergic Dermatitis,Photoallergies,Photocontact Dermatitides,Photocontact Dermatitis,Photosensitive Contact Dermatitides

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