-transparent.png){kind=logo}
Cultured skin fibroblasts from four patients with Alzheimer's disease had life spans comparable to those of six age-sex matched controls, whether measured by passages to phase-out, cumulative population doublings to phase out, or percentage of nuclei incorporating [3H]thymidine (Cristofalo index). These results provide direct experimental evidence that Alzheimer's disease is not simply a form of accelerated aging. They suggest that the abnormalities, described by several groups, in Alzheimer fibroblasts reflect the disease rather than the physiological age of the donor, making the cultured cell a valid tool for studying the cellular pathophysiology of this disorder. Together with other data, these observations raise the possibility that some forms of Alzheimer's disease may represent inborn error(s) of metabolism of late clinical onset.
A K Balin, and
A C Baker, and
I C Leong, and
J P Blass
August 2003,
Nature cell biology,
A K Balin, and
A C Baker, and
I C Leong, and
J P Blass
May 2009,
Human cell,
A K Balin, and
A C Baker, and
I C Leong, and
J P Blass
January 1997,
Experimental gerontology,
A K Balin, and
A C Baker, and
I C Leong, and
J P Blass
July 1991,
Archives of neurology,
A K Balin, and
A C Baker, and
I C Leong, and
J P Blass
January 2001,
Proceedings of the Western Pharmacology Society,
A K Balin, and
A C Baker, and
I C Leong, and
J P Blass
June 2019,
Rejuvenation research,
A K Balin, and
A C Baker, and
I C Leong, and
J P Blass
October 1979,
The Journal of biological chemistry,
A K Balin, and
A C Baker, and
I C Leong, and
J P Blass
September 1994,
Biochimica et biophysica acta,
A K Balin, and
A C Baker, and
I C Leong, and
J P Blass
March 2024,
Nature aging,
A K Balin, and
A C Baker, and
I C Leong, and
J P Blass
January 2024,
Methods in molecular biology (Clifton, N.J.),
