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The antigenic characteristics of 20 primary cerebral lymphomas have been defined by their reactivity with a panel of monoclonal antibodies recognizing differentiation antigens of lymphocytes and other cell types. In 7 out of 20 cases (35%), immunohistological results were diagnostically crucial and this approach appeared almost to double the detection rate of brain lymphomas over a 10-year period. All 20 tumours were confirmed as B-cell neoplasms by the use of a monoclonal antibody (B-1) specific for B-lymphocytes, rather than by the demonstration of immunoglobulin production. Further immunophenotyping with antibody FMC7 indicated that the neoplastic B-cells had been 'arrested' at a relatively mature stage of differentiation. The importance of monoclonal antibody markers in the accurate diagnosis and characterization of primary cerebral lymphomas has now been established.
J A Garson, and
S P Bourne, and
P M Allan, and
C Leather, and
D B Brownell, and
H B Coakham
June 2001,
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J A Garson, and
S P Bourne, and
P M Allan, and
C Leather, and
D B Brownell, and
H B Coakham
September 1985,
The Tohoku journal of experimental medicine,
J A Garson, and
S P Bourne, and
P M Allan, and
C Leather, and
D B Brownell, and
H B Coakham
January 1991,
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J A Garson, and
S P Bourne, and
P M Allan, and
C Leather, and
D B Brownell, and
H B Coakham
June 1988,
Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete,
J A Garson, and
S P Bourne, and
P M Allan, and
C Leather, and
D B Brownell, and
H B Coakham
April 1988,
Medicina clinica,
J A Garson, and
S P Bourne, and
P M Allan, and
C Leather, and
D B Brownell, and
H B Coakham
January 1990,
Voprosy onkologii,
J A Garson, and
S P Bourne, and
P M Allan, and
C Leather, and
D B Brownell, and
H B Coakham
August 1985,
Journal of the American Academy of Dermatology,
J A Garson, and
S P Bourne, and
P M Allan, and
C Leather, and
D B Brownell, and
H B Coakham
April 1995,
Transplantation proceedings,
J A Garson, and
S P Bourne, and
P M Allan, and
C Leather, and
D B Brownell, and
H B Coakham
January 1986,
Methods in enzymology,
J A Garson, and
S P Bourne, and
P M Allan, and
C Leather, and
D B Brownell, and
H B Coakham
June 1990,
Gematologiia i transfuziologiia,
