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Thalamic oscillatory activity may predict response to deep brain stimulation of the anterior nuclei of the thalamus. 2021

Barbora Deutschová, and Petr Klimeš, and Zsofia Jordan, and Pavel Jurák, and Lorand Erőss, and Martin Lamoš, and Josef Halámek, and Pavel Daniel, and Ivan Rektor, and Daniel Fabo
Brno Epilepsy Center, Department of Neurology, St. Anne's University Hospital and the Faculty of Medicine, Masaryk University, Brno, Czech Republic.

We hypothesized that local/regional properties of stimulated structure/circuitry contribute to the effect of deep brain stimulation (DBS). We analyzed intracerebral electroencephalographic (EEG) recordings from externalized DBS electrodes targeted bilaterally in the anterior nuclei of the thalamus (ANT) in 12 patients (six responders, six nonresponders) with more than 1 year of follow-up care. In the bipolar local field potentials of the EEG, spectral power (PW) and power spectral entropy (PSE) were calculated in the passbands 1-4, 4-8, 8-12, 12-20, 20-45, 65-80, 80-200 and 200-500 Hz. The most significant differences between responders and nonresponders were observed in the BRIDGE area (bipolar recordings with one contact within the ANT and the second contact in adjacent tissue). In responders, PW was significantly decreased in the frequency bands of 65-80, 80-200, and 200-500 Hz (p < .05); PSE was significantly increased in all frequency bands (p < .05) except for 200-500 Hz (p = .06). The local EEG characteristics of ANT recorded after implantation may play a significant role in DBS response prediction.

UI MeSH Term Description Entries
D004569 Electroencephalography Recording of electric currents developed in the brain by means of electrodes applied to the scalp, to the surface of the brain, or placed within the substance of the brain. EEG,Electroencephalogram,Electroencephalograms
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000069279 Drug Resistant Epilepsy Epileptic condition in which adequate trials of two tolerated and appropriately chosen and used ANTIEPILEPTIC DRUGS schedules to achieve sustained seizure freedom failed. Drug Refractory Epilepsy,Epilepsy, Drug Refractory,Epilepsy, Drug Resistant,Epilepsy, Intractable,Intractable Epilepsy,Medication Resistant Epilepsy,Refractory Epilepsy,Drug Refractory Epilepsies,Drug Resistant Epilepsies,Epilepsies, Drug Refractory,Epilepsies, Drug Resistant,Epilepsies, Intractable,Epilepsies, Medication Resistant,Epilepsies, Refractory,Epilepsy, Medication Resistant,Epilepsy, Refractory,Intractable Epilepsies,Medication Resistant Epilepsies,Refractory Epilepsies,Refractory Epilepsies, Drug,Refractory Epilepsy, Drug,Resistant Epilepsies, Drug,Resistant Epilepsies, Medication,Resistant Epilepsy, Drug,Resistant Epilepsy, Medication
D046690 Deep Brain Stimulation Therapy for MOVEMENT DISORDERS, especially PARKINSON DISEASE, that applies electricity via stereotactic implantation of ELECTRODES in specific areas of the BRAIN such as the THALAMUS. The electrodes are attached to a neurostimulator placed subcutaneously. Brain Stimulation, Deep,Electrical Stimulation of the Brain,Brain Stimulations, Deep,Deep Brain Stimulations,Stimulation, Deep Brain,Stimulations, Deep Brain
D020643 Anterior Thalamic Nuclei Three nuclei located beneath the dorsal surface of the most rostral part of the thalamus. The group includes the anterodorsal nucleus, anteromedial nucleus, and anteroventral nucleus. All receive connections from the MAMILLARY BODY and BRAIN FORNIX, and project fibers to the CINGULATE BODY. Anterior Nuclear Group,Anterodorsal Thalamic Nucleus,Anteromedial Thalamic Nucleus,Anteroventral Thalamic Nucleus,Anterior Nucleus of Thalamus,Anterior Thalamic Nucleus,Anterior Thalamus,Anterodorsal Nucleus,Anteromedial Nucleus,Anteroventral Nucleus,Nuclei, Anterior Thalamic,Nucleus, Anterodorsal,Nucleus, Anterodorsal Thalamic,Nucleus, Anteromedial,Nucleus, Anteromedial Thalamic,Nucleus, Anteroventral,Nucleus, Anteroventral Thalamic,Thalamic Nuclei, Anterior,Thalamic Nucleus, Anterodorsal,Thalamic Nucleus, Anteromedial,Thalamic Nucleus, Anteroventral,Thalamus Anterior Nucleus,Thalamus, Anterior

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