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Quadrivalent influenza nanoparticle vaccines induce broad protection. 2021
Seyhan Boyoglu-Barnum, and
Daniel Ellis, and
Rebecca A Gillespie, and
Geoffrey B Hutchinson, and
Young-Jun Park, and
Syed M Moin, and
Oliver J Acton, and
Rashmi Ravichandran, and
Mike Murphy, and
Deleah Pettie, and
Nick Matheson, and
Lauren Carter, and
Adrian Creanga, and
Michael J Watson, and
Sally Kephart, and
Sila Ataca, and
John R Vaile, and
George Ueda, and
Michelle C Crank, and
Lance Stewart, and
Kelly K Lee, and
Miklos Guttman, and
David Baker, and
John R Mascola, and
David Veesler, and
Barney S Graham, and
Neil P King, and
Masaru Kanekiyo
Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
Influenza vaccines that confer broad and durable protection against diverse viral strains would have a major effect on global health, as they would lessen the need for annual vaccine reformulation and immunization1. Here we show that computationally designed, two-component nanoparticle immunogens2 induce potently neutralizing and broadly protective antibody responses against a wide variety of influenza viruses. The nanoparticle immunogens contain 20 haemagglutinin glycoprotein trimers in an ordered array, and their assembly in vitro enables the precisely controlled co-display of multiple distinct haemagglutinin proteins in defined ratios. Nanoparticle immunogens that co-display the four haemagglutinins of licensed quadrivalent influenza vaccines elicited antibody responses in several animal models against vaccine-matched strains that were equivalent to or better than commercial quadrivalent influenza vaccines, and simultaneously induced broadly protective antibody responses to heterologous viruses by targeting the subdominant yet conserved haemagglutinin stem. The combination of potent receptor-blocking and cross-reactive stem-directed antibodies induced by the nanoparticle immunogens makes them attractive candidates for a supraseasonal influenza vaccine candidate with the potential to replace conventional seasonal vaccines3.
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Syed M Moin, and
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Rashmi Ravichandran, and
Mike Murphy, and
Deleah Pettie, and
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Adrian Creanga, and
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Rashmi Ravichandran, and
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Sally Kephart, and
Sila Ataca, and
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Rashmi Ravichandran, and
Mike Murphy, and
Deleah Pettie, and
Nick Matheson, and
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Sally Kephart, and
Sila Ataca, and
John R Vaile, and
George Ueda, and
Michelle C Crank, and
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Nanomedicine : nanotechnology, biology, and medicine,
