Biomaterial Database

Nutrition of the intervertebral disc: acute effects of cigarette smoking. An experimental animal study. 1988

S Holm, and A Nachemson

Department of Orthopaedics, University of Göteborg, Sahlgren Hospital, Sweden.

We have in the present experimental study investigated the influence of cigarette smoking on some nutritional parameters of the porcine intervertebral disc. The results from the acute smoking tests show a significant reduction in solute transport. Diffusion of sulphate, oxygen and methyl glucose was reduced by 30-40 per cent. This effect was obtained after exposure to smoke for 20-30 minutes. A smoking period of three hours reduced the transport efficiency to about 50 per cent. The effect of smoking decreased when the exposure ceased. The concentration gradients were close to normal after 2 hours "recovery". These findings suggest that cigarette smoking not only significantly affects the circulatory system outside the intervertebral disc, where the most pronounced effect is the reduction in solute exchange capacity, but also significantly deteriorates the cellular uptake rate and metabolite production within the disc.

UI	MeSH Term	Description	Entries
D007403	Intervertebral Disc	Any of the 23 plates of fibrocartilage found between the bodies of adjacent VERTEBRAE.	Disk, Intervertebral,Intervertebral Disk,Disc, Intervertebral,Discs, Intervertebral,Disks, Intervertebral,Intervertebral Discs,Intervertebral Disks
D008297	Male		Males
D008757	Methylglucosides		Methylglucopyranosides
D010101	Oxygen Consumption	The rate at which oxygen is used by a tissue; microliters of oxygen STPD used per milligram of tissue per hour; the rate at which oxygen enters the blood from alveolar gas, equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body. (Stedman, 25th ed, p346)	Consumption, Oxygen,Consumptions, Oxygen,Oxygen Consumptions
D002196	Capillaries	The minute vessels that connect arterioles and venules.	Capillary Beds,Sinusoidal Beds,Sinusoids,Bed, Sinusoidal,Beds, Sinusoidal,Capillary,Capillary Bed,Sinusoid,Sinusoidal Bed
D005260	Female		Females
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D001693	Biological Transport, Active	The movement of materials across cell membranes and epithelial layers against an electrochemical gradient, requiring the expenditure of metabolic energy.	Active Transport,Uphill Transport,Active Biological Transport,Biologic Transport, Active,Transport, Active Biological,Active Biologic Transport,Transport, Active,Transport, Active Biologic,Transport, Uphill
D012907	Smoking	Willful or deliberate act of inhaling and exhaling SMOKE from burning substances or agents held by hand.	Smoking Behaviors,Smoking Habit,Behavior, Smoking,Behaviors, Smoking,Habit, Smoking,Habits, Smoking,Smoking Behavior,Smoking Habits
D013431	Sulfates	Inorganic salts of sulfuric acid.	Sulfate,Sulfates, Inorganic,Inorganic Sulfates