Biomaterial Database

Perforating gastric ulceration during tolazoline therapy for persistent foetal circulation. 1988

K E von Mühlendahl

Kinderhospital Osnabrück.

Gastric ulcerations were observed in an infant with persistent foetal circulation treated with tolazoline. The first symptoms were noted 14 hours after institution of therapy, and free air in the abdomen was visualised 34 hours later. It is suggested that the ulcerations may have been a side effect of tolazoline. The concomitant use of cimetidine may prevent this complication.

UI	MeSH Term	Description	Entries
D007231	Infant, Newborn	An infant during the first 28 days after birth.	Neonate,Newborns,Infants, Newborn,Neonates,Newborn,Newborn Infant,Newborn Infants
D010439	Peptic Ulcer Perforation	Penetration of a PEPTIC ULCER through the wall of DUODENUM or STOMACH allowing the leakage of luminal contents into the PERITONEAL CAVITY.	Peptic Ulcer Perforations,Perforation, Peptic Ulcer,Perforations, Peptic Ulcer,Ulcer Perforation, Peptic,Ulcer Perforations, Peptic
D010547	Persistent Fetal Circulation Syndrome	A syndrome of persistent PULMONARY HYPERTENSION in the newborn infant (INFANT, NEWBORN) without demonstrable HEART DISEASES. This neonatal condition can be caused by severe pulmonary vasoconstriction (reactive type), hypertrophy of pulmonary arterial muscle (hypertrophic type), or abnormally developed pulmonary arterioles (hypoplastic type). The newborn patient exhibits CYANOSIS and ACIDOSIS due to the persistence of fetal circulatory pattern of right-to-left shunting of blood through a patent ductus arteriosus (DUCTUS ARTERIOSUS, PATENT) and at times a patent foramen ovale (FORAMEN OVALE, PATENT).	Fetal Circulation, Persistent,Hypertension, Pulmonary, of Newborn, Persistent,Persistent Pulmonary Hypertension of Newborn,ACD-MPV,ACDMPV,Alveolar Capillary Dysplasia With Misalignment Of Pulmonary Veins,Alveolar Capillary Dysplasia With Misalignment Of Pulmonary Veins And Other Congenital Anomalies,Circulation, Persistent Fetal,Familial Persistent Pulmonary Hypertension of the Newborn,Misalignment of the Pulmonary Vessels,Persistent Fetal Circulation,Pulmonary Hypertension, Familial Persistent, of the Newborn,ACD MPV
D005260	Female		Females
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D013276	Stomach Ulcer	Ulceration of the GASTRIC MUCOSA due to contact with GASTRIC JUICE. It is often associated with HELICOBACTER PYLORI infection or consumption of nonsteroidal anti-inflammatory drugs (NSAIDS).	Gastric Ulcer,Gastric Ulcers,Stomach Ulcers,Ulcer, Gastric,Ulcer, Stomach,Ulcers, Gastric,Ulcers, Stomach
D014043	Tolazoline	A vasodilator that apparently has direct actions on blood vessels and also increases cardiac output. Tolazoline can interact to some degree with histamine, adrenergic, and cholinergic receptors, but the mechanisms of its therapeutic effects are not clear. It is used in treatment of persistent pulmonary hypertension of the newborn.	Benzalolin,Divascol,Pridazole,Priscol,Priscoline,Tolazoline Hydrochloride,Tolazoline Monohydrochloride