-transparent.png){kind=logo}
mRNA vaccination boosts cross-variant neutralizing antibodies elicited by SARS-CoV-2 infection. 2021
Leonidas Stamatatos, and
Julie Czartoski, and
Yu-Hsin Wan, and
Leah J Homad, and
Vanessa Rubin, and
Hayley Glantz, and
Moni Neradilek, and
Emilie Seydoux, and
Madeleine F Jennewein, and
Anna J MacCamy, and
Junli Feng, and
Gregory Mize, and
Stephen C De Rosa, and
Andrés Finzi, and
Maria P Lemos, and
Kristen W Cohen, and
Zoe Moodie, and
M Juliana McElrath, and
Andrew T McGuire
Fred Hutchinson Cancer Research Center, Vaccine and Infectious Disease Division, Seattle, WA, USA. amcguire@fredhutch.org lstamata@fredhutch.org jmcelrat@fredhutch.org.
Emerging SARS-CoV-2 variants have raised concerns about resistance to neutralizing antibodies elicited by previous infection or vaccination. We examined whether sera from recovered and naïve donors collected prior to, and following immunizations with existing mRNA vaccines, could neutralize the Wuhan-Hu-1 and B.1.351 variants. Pre-vaccination sera from recovered donors neutralized Wuhan-Hu-1 and sporadically neutralized B.1.351, but a single immunization boosted neutralizing titers against all variants and SARS-CoV-1 by up to 1000-fold. Neutralization was due to antibodies targeting the receptor binding domain and was not boosted by a second immunization. Immunization of naïve donors also elicited cross-neutralizing responses, but at lower titers. Our study highlights the importance of vaccinating both uninfected and previously infected persons to elicit cross-variant neutralizing antibodies.
| UI | MeSH Term | Description | Entries |
|---|
Related Publications
Leonidas Stamatatos, and
Julie Czartoski, and
Yu-Hsin Wan, and
Leah J Homad, and
Vanessa Rubin, and
Hayley Glantz, and
Moni Neradilek, and
Emilie Seydoux, and
Madeleine F Jennewein, and
Anna J MacCamy, and
Junli Feng, and
Gregory Mize, and
Stephen C De Rosa, and
Andrés Finzi, and
Maria P Lemos, and
Kristen W Cohen, and
Zoe Moodie, and
M Juliana McElrath, and
Andrew T McGuire
August 2020,
Nature,
Leonidas Stamatatos, and
Julie Czartoski, and
Yu-Hsin Wan, and
Leah J Homad, and
Vanessa Rubin, and
Hayley Glantz, and
Moni Neradilek, and
Emilie Seydoux, and
Madeleine F Jennewein, and
Anna J MacCamy, and
Junli Feng, and
Gregory Mize, and
Stephen C De Rosa, and
Andrés Finzi, and
Maria P Lemos, and
Kristen W Cohen, and
Zoe Moodie, and
M Juliana McElrath, and
Andrew T McGuire
May 2022,
Vaccines,
Leonidas Stamatatos, and
Julie Czartoski, and
Yu-Hsin Wan, and
Leah J Homad, and
Vanessa Rubin, and
Hayley Glantz, and
Moni Neradilek, and
Emilie Seydoux, and
Madeleine F Jennewein, and
Anna J MacCamy, and
Junli Feng, and
Gregory Mize, and
Stephen C De Rosa, and
Andrés Finzi, and
Maria P Lemos, and
Kristen W Cohen, and
Zoe Moodie, and
M Juliana McElrath, and
Andrew T McGuire
February 2022,
Viruses,
Leonidas Stamatatos, and
Julie Czartoski, and
Yu-Hsin Wan, and
Leah J Homad, and
Vanessa Rubin, and
Hayley Glantz, and
Moni Neradilek, and
Emilie Seydoux, and
Madeleine F Jennewein, and
Anna J MacCamy, and
Junli Feng, and
Gregory Mize, and
Stephen C De Rosa, and
Andrés Finzi, and
Maria P Lemos, and
Kristen W Cohen, and
Zoe Moodie, and
M Juliana McElrath, and
Andrew T McGuire
March 2024,
bioRxiv : the preprint server for biology,
Leonidas Stamatatos, and
Julie Czartoski, and
Yu-Hsin Wan, and
Leah J Homad, and
Vanessa Rubin, and
Hayley Glantz, and
Moni Neradilek, and
Emilie Seydoux, and
Madeleine F Jennewein, and
Anna J MacCamy, and
Junli Feng, and
Gregory Mize, and
Stephen C De Rosa, and
Andrés Finzi, and
Maria P Lemos, and
Kristen W Cohen, and
Zoe Moodie, and
M Juliana McElrath, and
Andrew T McGuire
June 2022,
The Journal of infection,
Leonidas Stamatatos, and
Julie Czartoski, and
Yu-Hsin Wan, and
Leah J Homad, and
Vanessa Rubin, and
Hayley Glantz, and
Moni Neradilek, and
Emilie Seydoux, and
Madeleine F Jennewein, and
Anna J MacCamy, and
Junli Feng, and
Gregory Mize, and
Stephen C De Rosa, and
Andrés Finzi, and
Maria P Lemos, and
Kristen W Cohen, and
Zoe Moodie, and
M Juliana McElrath, and
Andrew T McGuire
March 2022,
Science translational medicine,
Leonidas Stamatatos, and
Julie Czartoski, and
Yu-Hsin Wan, and
Leah J Homad, and
Vanessa Rubin, and
Hayley Glantz, and
Moni Neradilek, and
Emilie Seydoux, and
Madeleine F Jennewein, and
Anna J MacCamy, and
Junli Feng, and
Gregory Mize, and
Stephen C De Rosa, and
Andrés Finzi, and
Maria P Lemos, and
Kristen W Cohen, and
Zoe Moodie, and
M Juliana McElrath, and
Andrew T McGuire
November 2023,
The journal of allergy and clinical immunology. Global,
Leonidas Stamatatos, and
Julie Czartoski, and
Yu-Hsin Wan, and
Leah J Homad, and
Vanessa Rubin, and
Hayley Glantz, and
Moni Neradilek, and
Emilie Seydoux, and
Madeleine F Jennewein, and
Anna J MacCamy, and
Junli Feng, and
Gregory Mize, and
Stephen C De Rosa, and
Andrés Finzi, and
Maria P Lemos, and
Kristen W Cohen, and
Zoe Moodie, and
M Juliana McElrath, and
Andrew T McGuire
November 2021,
Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases,
Leonidas Stamatatos, and
Julie Czartoski, and
Yu-Hsin Wan, and
Leah J Homad, and
Vanessa Rubin, and
Hayley Glantz, and
Moni Neradilek, and
Emilie Seydoux, and
Madeleine F Jennewein, and
Anna J MacCamy, and
Junli Feng, and
Gregory Mize, and
Stephen C De Rosa, and
Andrés Finzi, and
Maria P Lemos, and
Kristen W Cohen, and
Zoe Moodie, and
M Juliana McElrath, and
Andrew T McGuire
March 2022,
Science translational medicine,
Leonidas Stamatatos, and
Julie Czartoski, and
Yu-Hsin Wan, and
Leah J Homad, and
Vanessa Rubin, and
Hayley Glantz, and
Moni Neradilek, and
Emilie Seydoux, and
Madeleine F Jennewein, and
Anna J MacCamy, and
Junli Feng, and
Gregory Mize, and
Stephen C De Rosa, and
Andrés Finzi, and
Maria P Lemos, and
Kristen W Cohen, and
Zoe Moodie, and
M Juliana McElrath, and
Andrew T McGuire
May 2021,
JAMA,
