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Sixteen patients suffering from spasticity due to multiple sclerosis were treated with baclofen and tizanidine in a partially blind cross-over study. No significant difference in efficacy was found. The most striking difference was seen in the side-effects: baclofen frequently caused more or less severe muscle weakness and even falling during walking and standing. Treatment with tizanidine produced an apparent improvement of mobility in some patients suffering from moderate or marked paresis associated with a marked spasticity of their legs. Isometric muscle strength did not show any significant changes during either treatment. The different impact of baclofen and tizanidine on mobility and weight support seems to be related to their different site of action in spasticity.
M C Hoogstraten, and
R J van der Ploeg, and
W vd Burg, and
A Vreeling, and
S van Marle, and
J M Minderhoud
February 1988,
The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques,
M C Hoogstraten, and
R J van der Ploeg, and
W vd Burg, and
A Vreeling, and
S van Marle, and
J M Minderhoud
November 1989,
The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques,
M C Hoogstraten, and
R J van der Ploeg, and
W vd Burg, and
A Vreeling, and
S van Marle, and
J M Minderhoud
August 1987,
The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques,
M C Hoogstraten, and
R J van der Ploeg, and
W vd Burg, and
A Vreeling, and
S van Marle, and
J M Minderhoud
August 1975,
American journal of physical medicine,
M C Hoogstraten, and
R J van der Ploeg, and
W vd Burg, and
A Vreeling, and
S van Marle, and
J M Minderhoud
February 2006,
Multiple sclerosis (Houndmills, Basingstoke, England),
M C Hoogstraten, and
R J van der Ploeg, and
W vd Burg, and
A Vreeling, and
S van Marle, and
J M Minderhoud
August 1979,
The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques,
M C Hoogstraten, and
R J van der Ploeg, and
W vd Burg, and
A Vreeling, and
S van Marle, and
J M Minderhoud
March 1987,
Acta neurologica Scandinavica,
M C Hoogstraten, and
R J van der Ploeg, and
W vd Burg, and
A Vreeling, and
S van Marle, and
J M Minderhoud
January 1981,
Current medical research and opinion,
M C Hoogstraten, and
R J van der Ploeg, and
W vd Burg, and
A Vreeling, and
S van Marle, and
J M Minderhoud
September 1975,
Postgraduate medical journal,
M C Hoogstraten, and
R J van der Ploeg, and
W vd Burg, and
A Vreeling, and
S van Marle, and
J M Minderhoud
January 2007,
Acta neurochirurgica. Supplement,
