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We conducted a placebo-controlled double-blind investigation in 15 normal volunteers to study the time course of amnesia to auditory stimulation produced by lorazepam. We also studied the relationship between auditory amnesia and auditory evoked potentials to determine if long-latency auditory evoked potentials (LLAEPs) could be utilized as electrophysiologic predictors of memory. Amnesia was produced by administration of 0.05 mg/kg lorazepam intravenously. To separate the changes in LLAEPs due to generalized sedation from those associated with amnestic properties of a drug, a third group of subjects given 1.5 mg/kg secobarbital was included. Observed frequency and duration of amnesia to auditory stimulation after lorazepam was 58% and 3 hours, respectively (mean values), with marked diminuition of antirecall effect at 120 minutes. Administration of lorazepam increased the latency and decreased the amplitude of N1 and P3 components of LLAEPs. These changes appeared to be a result of generalized sedation rather than the amnestic properties of the drug. We failed to find a definite relationship between amnesia and changes in LLAEPs. We conclude that P3 component of LLAEPs cannot be utilized as an electrophysiologic predictor of amnesia in humans.
S K Samra, and
E G Bradshaw, and
S K Pandit, and
A C Papanicolaou, and
B D Moore
February 2018,
Basic & clinical pharmacology & toxicology,
S K Samra, and
E G Bradshaw, and
S K Pandit, and
A C Papanicolaou, and
B D Moore
February 2008,
Schizophrenia research,
S K Samra, and
E G Bradshaw, and
S K Pandit, and
A C Papanicolaou, and
B D Moore
January 1984,
Psychopharmacology,
S K Samra, and
E G Bradshaw, and
S K Pandit, and
A C Papanicolaou, and
B D Moore
January 1972,
Comptes rendus des seances de la Societe de biologie et de ses filiales,
S K Samra, and
E G Bradshaw, and
S K Pandit, and
A C Papanicolaou, and
B D Moore
April 2007,
Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology,
S K Samra, and
E G Bradshaw, and
S K Pandit, and
A C Papanicolaou, and
B D Moore
March 2006,
Best practice & research. Clinical anaesthesiology,
S K Samra, and
E G Bradshaw, and
S K Pandit, and
A C Papanicolaou, and
B D Moore
March 2006,
Masui. The Japanese journal of anesthesiology,
S K Samra, and
E G Bradshaw, and
S K Pandit, and
A C Papanicolaou, and
B D Moore
April 1991,
Otolaryngologic clinics of North America,
S K Samra, and
E G Bradshaw, and
S K Pandit, and
A C Papanicolaou, and
B D Moore
May 2004,
Minerva anestesiologica,
S K Samra, and
E G Bradshaw, and
S K Pandit, and
A C Papanicolaou, and
B D Moore
September 2019,
Medical hypotheses,
