Prediction of hematoma expansion in spontaneous intracerebral hemorrhage: Our institutional experience. 2021

Kevin Hines, and Nikolaos Mouchtouris, and Fadi Al Saiegh, and Karim Hafazalla, and Jacob Mazza, and Phillip Phan, and M Reid Gooch, and Stavropoula Tjoumakaris, and Robert H Rosenwasser, and Pascal M Jabbour
Department of Neurosurgery, Thomas Jefferson University and Jefferson Hospital for Neuroscience, Philadelphia, PA, United States.

BACKGROUND Spontaneous intracerebral hemorrhage (sICH) is a disease process with high morbidity and mortality. In particular, hematoma expansion (HE) is a feared complication of sICH. With 15-40% of patients experiencing HE, it has become increasingly important to predict which sICH will remain stable and which will expand. OBJECTIVE With new treatment options being developed, it is becoming increasingly important to be able to predict which hemorrhages are at high versus low risk for expansion. The authors of this study hope to reexamine variables associated with hematoma expansion in hopes of generating newer data on risk factors for expansion. METHODS A retrospective analysis identified 334 patients who presented with sICH. The primary outcome was HE on follow up head CT. HE was defined as a greater than 33% increase or an absolute increase in 6 mL or more in overall volume between the two sets of CT images. Analysis was performed using unpaired t-test, Chi-square, and Fisher's exact tests, as appropriate. RESULTS Of the 334 patients, 247 (74.0%) did not experience an expansion of their ICH while 87 (26.0%) did. Multivariable logistic regression was performed demonstrating ICH score of 3 or greater (4.76 (95% CI 2.60-8.72, p < 0.001) , cortical location of the sICH (1.77 (95% CI 1.03-3.04, p = 0.038), and presence of a fluid level (6.46 (95% CI 2.28-18.3, p < 0.001) as significant predictors of HE. CONCLUSIONS Our study found that fluid-fluid levels on non-contrast CT, an ICH score 3 or greater, and lobar sICH were all more likely to expand.

UI MeSH Term Description Entries
D008297 Male Males
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D011237 Predictive Value of Tests In screening and diagnostic tests, the probability that a person with a positive test is a true positive (i.e., has the disease), is referred to as the predictive value of a positive test; whereas, the predictive value of a negative test is the probability that the person with a negative test does not have the disease. Predictive value is related to the sensitivity and specificity of the test. Negative Predictive Value,Positive Predictive Value,Predictive Value Of Test,Predictive Values Of Tests,Negative Predictive Values,Positive Predictive Values,Predictive Value, Negative,Predictive Value, Positive
D002543 Cerebral Hemorrhage Bleeding into one or both CEREBRAL HEMISPHERES including the BASAL GANGLIA and the CEREBRAL CORTEX. It is often associated with HYPERTENSION and CRANIOCEREBRAL TRAUMA. Brain Hemorrhage, Cerebral,Cerebral Parenchymal Hemorrhage,Hemorrhage, Cerebral,Intracerebral Hemorrhage,Hemorrhage, Cerebrum,Brain Hemorrhages, Cerebral,Cerebral Brain Hemorrhage,Cerebral Brain Hemorrhages,Cerebral Hemorrhages,Cerebral Parenchymal Hemorrhages,Cerebrum Hemorrhage,Cerebrum Hemorrhages,Hemorrhage, Cerebral Brain,Hemorrhage, Cerebral Parenchymal,Hemorrhage, Intracerebral,Hemorrhages, Cerebral,Hemorrhages, Cerebral Brain,Hemorrhages, Cerebral Parenchymal,Hemorrhages, Cerebrum,Hemorrhages, Intracerebral,Intracerebral Hemorrhages,Parenchymal Hemorrhage, Cerebral,Parenchymal Hemorrhages, Cerebral
D005260 Female Females
D005500 Follow-Up Studies Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease. Followup Studies,Follow Up Studies,Follow-Up Study,Followup Study,Studies, Follow-Up,Studies, Followup,Study, Follow-Up,Study, Followup
D006406 Hematoma A collection of blood outside the BLOOD VESSELS. Hematoma can be localized in an organ, space, or tissue. Hematomas
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000368 Aged A person 65 years of age or older. For a person older than 79 years, AGED, 80 AND OVER is available. Elderly
D012189 Retrospective Studies Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons. Retrospective Study,Studies, Retrospective,Study, Retrospective

Related Publications

Kevin Hines, and Nikolaos Mouchtouris, and Fadi Al Saiegh, and Karim Hafazalla, and Jacob Mazza, and Phillip Phan, and M Reid Gooch, and Stavropoula Tjoumakaris, and Robert H Rosenwasser, and Pascal M Jabbour
May 2019, EBioMedicine,
Kevin Hines, and Nikolaos Mouchtouris, and Fadi Al Saiegh, and Karim Hafazalla, and Jacob Mazza, and Phillip Phan, and M Reid Gooch, and Stavropoula Tjoumakaris, and Robert H Rosenwasser, and Pascal M Jabbour
December 2014, The International journal of neuroscience,
Kevin Hines, and Nikolaos Mouchtouris, and Fadi Al Saiegh, and Karim Hafazalla, and Jacob Mazza, and Phillip Phan, and M Reid Gooch, and Stavropoula Tjoumakaris, and Robert H Rosenwasser, and Pascal M Jabbour
July 2013, Clinical neurology and neurosurgery,
Kevin Hines, and Nikolaos Mouchtouris, and Fadi Al Saiegh, and Karim Hafazalla, and Jacob Mazza, and Phillip Phan, and M Reid Gooch, and Stavropoula Tjoumakaris, and Robert H Rosenwasser, and Pascal M Jabbour
February 2014, JAMA neurology,
Kevin Hines, and Nikolaos Mouchtouris, and Fadi Al Saiegh, and Karim Hafazalla, and Jacob Mazza, and Phillip Phan, and M Reid Gooch, and Stavropoula Tjoumakaris, and Robert H Rosenwasser, and Pascal M Jabbour
February 2010, Stroke,
Kevin Hines, and Nikolaos Mouchtouris, and Fadi Al Saiegh, and Karim Hafazalla, and Jacob Mazza, and Phillip Phan, and M Reid Gooch, and Stavropoula Tjoumakaris, and Robert H Rosenwasser, and Pascal M Jabbour
July 2022, Scientific reports,
Kevin Hines, and Nikolaos Mouchtouris, and Fadi Al Saiegh, and Karim Hafazalla, and Jacob Mazza, and Phillip Phan, and M Reid Gooch, and Stavropoula Tjoumakaris, and Robert H Rosenwasser, and Pascal M Jabbour
April 2014, Stroke,
Kevin Hines, and Nikolaos Mouchtouris, and Fadi Al Saiegh, and Karim Hafazalla, and Jacob Mazza, and Phillip Phan, and M Reid Gooch, and Stavropoula Tjoumakaris, and Robert H Rosenwasser, and Pascal M Jabbour
January 2019, Annals of Indian Academy of Neurology,
Kevin Hines, and Nikolaos Mouchtouris, and Fadi Al Saiegh, and Karim Hafazalla, and Jacob Mazza, and Phillip Phan, and M Reid Gooch, and Stavropoula Tjoumakaris, and Robert H Rosenwasser, and Pascal M Jabbour
January 2020, Frontiers in neurology,
Kevin Hines, and Nikolaos Mouchtouris, and Fadi Al Saiegh, and Karim Hafazalla, and Jacob Mazza, and Phillip Phan, and M Reid Gooch, and Stavropoula Tjoumakaris, and Robert H Rosenwasser, and Pascal M Jabbour
January 2008, Surgical neurology,
Copied contents to your clipboard!