-transparent.png){kind=logo}
From April 8, 1982, through June 1984, 11 patients in a single hospital experienced 17 episodes of limb edema and discoloration after the intravenous (IV) administration of phenytoin sodium (Dilantin). One patient required a below-the-elbow amputation; all other patients recovered. No single drug lot was implicated. A case-control study was performed using three controls for each case; controls received IV infusions of phenytoin and were hospitalized close in time to the case patients. Compared with controls, patients with reactions were more often female and elderly and had underlying cardiovascular disease. Affected patients also received phenytoin through an IV catheter smaller than 20 gauge (50% vs 6%), at a rate greater than 25 mg/min (63% vs 19%), and in two or more IV infusions of phenytoin given "IV push" at the same site (81% vs 24%). High-risk patients require careful monitoring and stricter guidelines for the IV administration of phenytoin.
R F Spengler, and
J B Arrowsmith, and
D J Kilarski, and
C Buchanan, and
L Von Behren, and
D R Graham
August 1989,
Archives of internal medicine,
R F Spengler, and
J B Arrowsmith, and
D J Kilarski, and
C Buchanan, and
L Von Behren, and
D R Graham
March 1998,
Deutsche medizinische Wochenschrift (1946),
R F Spengler, and
J B Arrowsmith, and
D J Kilarski, and
C Buchanan, and
L Von Behren, and
D R Graham
September 1988,
Drug intelligence & clinical pharmacy,
R F Spengler, and
J B Arrowsmith, and
D J Kilarski, and
C Buchanan, and
L Von Behren, and
D R Graham
November 1994,
Acta paediatrica (Oslo, Norway : 1992),
R F Spengler, and
J B Arrowsmith, and
D J Kilarski, and
C Buchanan, and
L Von Behren, and
D R Graham
July 1995,
Cancer,
R F Spengler, and
J B Arrowsmith, and
D J Kilarski, and
C Buchanan, and
L Von Behren, and
D R Graham
February 1991,
Annals of emergency medicine,
R F Spengler, and
J B Arrowsmith, and
D J Kilarski, and
C Buchanan, and
L Von Behren, and
D R Graham
November 1984,
The New England journal of medicine,
R F Spengler, and
J B Arrowsmith, and
D J Kilarski, and
C Buchanan, and
L Von Behren, and
D R Graham
August 2011,
Archives of disease in childhood,
R F Spengler, and
J B Arrowsmith, and
D J Kilarski, and
C Buchanan, and
L Von Behren, and
D R Graham
February 2007,
Vascular medicine (London, England),
R F Spengler, and
J B Arrowsmith, and
D J Kilarski, and
C Buchanan, and
L Von Behren, and
D R Graham
January 1986,
Developmental pharmacology and therapeutics,
