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Roxithromycin sputum and serum concentrations after administration of therapeutic doses (150 mg in a single dose) were evaluated in six patients. Blood samples and pooled sputum samples were collected at corresponding time intervals up to 24 h after drug administration. Roxithromycin sputum levels were found to be almost always above serum concentrations, the highest sputum levels being 5.85 +/- 2.5 micrograms/ml in the interval ranging from 2 to 4 h after drug administration. Due to its antibacterial spectrum and favourable pharmacokinetic properties, roxithromycin, like other macrolide antibiotics, seems to be particularly indicated in the treatment of respiratory tract infections.
V De Rose, and
A Ferrara, and
P Mangiarotti, and
A Nonis, and
R Bertoletti, and
G Gialdroni Grassi
January 1991,
Chemotherapy,
V De Rose, and
A Ferrara, and
P Mangiarotti, and
A Nonis, and
R Bertoletti, and
G Gialdroni Grassi
October 1987,
The Journal of antimicrobial chemotherapy,
V De Rose, and
A Ferrara, and
P Mangiarotti, and
A Nonis, and
R Bertoletti, and
G Gialdroni Grassi
May 1987,
Antimicrobial agents and chemotherapy,
V De Rose, and
A Ferrara, and
P Mangiarotti, and
A Nonis, and
R Bertoletti, and
G Gialdroni Grassi
January 1987,
Drugs,
V De Rose, and
A Ferrara, and
P Mangiarotti, and
A Nonis, and
R Bertoletti, and
G Gialdroni Grassi
March 1989,
Antimicrobial agents and chemotherapy,
V De Rose, and
A Ferrara, and
P Mangiarotti, and
A Nonis, and
R Bertoletti, and
G Gialdroni Grassi
June 1982,
Pathologie-biologie,
V De Rose, and
A Ferrara, and
P Mangiarotti, and
A Nonis, and
R Bertoletti, and
G Gialdroni Grassi
January 1982,
Reviews of infectious diseases,
V De Rose, and
A Ferrara, and
P Mangiarotti, and
A Nonis, and
R Bertoletti, and
G Gialdroni Grassi
April 1986,
European journal of clinical microbiology,
V De Rose, and
A Ferrara, and
P Mangiarotti, and
A Nonis, and
R Bertoletti, and
G Gialdroni Grassi
April 1986,
Chemioterapia : international journal of the Mediterranean Society of Chemotherapy,
V De Rose, and
A Ferrara, and
P Mangiarotti, and
A Nonis, and
R Bertoletti, and
G Gialdroni Grassi
January 1984,
Chemotherapy,
