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The renal clearances of a homologous series of six 5-substituted barbituric acids, of varying lipophilicity, were examined using a recirculating isolated perfused rat kidney preparation. Renal clearance was found to decrease with increasing lipophilicity. The renal clearance of the individual compounds was shown to be dependent on urine flow, with the dependence increasing with increasing lipophilicity. A simple physiologically based model of tubular reabsorption, evoking nonequilibrium permeability considerations, is used to explain this influence of urine flow on renal clearance. The relationship between clearance and tubular permeability was examined with the purpose of integrating lipophilicity into the model.
J M Mayer, and
S D Hall, and
M Rowland
June 1986,
Clinical science (London, England : 1979),
J M Mayer, and
S D Hall, and
M Rowland
January 1979,
Medicina,
J M Mayer, and
S D Hall, and
M Rowland
April 1973,
The Journal of physiology,
J M Mayer, and
S D Hall, and
M Rowland
January 1993,
Drug metabolism and disposition: the biological fate of chemicals,
J M Mayer, and
S D Hall, and
M Rowland
May 1989,
The American journal of physiology,
J M Mayer, and
S D Hall, and
M Rowland
January 1994,
Experimental nephrology,
J M Mayer, and
S D Hall, and
M Rowland
January 1976,
Research communications in chemical pathology and pharmacology,
J M Mayer, and
S D Hall, and
M Rowland
June 1985,
Kidney international,
J M Mayer, and
S D Hall, and
M Rowland
October 1984,
The American journal of physiology,
J M Mayer, and
S D Hall, and
M Rowland
January 1995,
Archives of toxicology,
