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Ignoring a basic pathophysiological mechanism of heart failure progression will not make it go away. 2021
A Martin Gerdes, and
Michael A Portman, and
Giorgio Iervasi, and
Alessandro Pingitore, and
David K C Cooper, and
Dimitri Novitzky
Department of Biomedical Sciences, New York Institute of Technology, College of Osteopathic Medicine, Old Westbury, New York.
A link between heart failure (HF) and low thyroid hormone (TH) function has been known for over a century. Nonetheless, there is a general belief that TH treatment of patients with HF may not be worth the risk. This is largely based on two clinical trials where heart patients were treated with excessive doses of TH analogs, not actual THs. Further complicating the matter is the fact that normalization of THs in noncardiac patients can often be challenging. This issue is not going away as noted by a steady increase in TH-HF citations in recent years. In this article, we discuss what we know and how we may move the field forward.
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