Multi-walled carbon nanotube polysaccharide modified Hericium erinaceus polysaccharide as an adjuvant to extend immune responses. 2021

Zhe Ren, and Yang Luo, and Zhen Meng, and Junwen Zhang, and Ruihong Yu, and Mengke Sun, and Ting Xu, and Jian Li, and Yufang Ma, and Yifan Huang, and Tao Qin
Key Laboratory of Traditional Chinese Veterinary Medicine and Animal Health in Fujian Province, Fujian Agriculture and Forestry University, Fuzhou 350002, PR China.

In recent years, the utilization of CS-MWCNT as targeted drug carriers has attracted considerable attention. Hericium erinaceus polysaccharide (HEP) has been reported as an immunostimulant to improve immune responses. This study was focussed on developing CS-MWCNT encapsulating HEP (CS-MWCNT-HEP). Using in mice peritoneal macrophages, we found the immune response could be effectively regulated by CS-MWCNT-HEP, promoted the expression of the MHCII, CD86, F4/80 and gp38. Moreover, the mice immunized with CS-MWCNT-HEP nanoparticles significantly extended PCV2-specific IgG immune response and the levels of cytokines. The results demonstrated that CS-MWCNT-HEP may be a promising drug delivery system for immuno-enhancement.

UI MeSH Term Description Entries
D008813 Mice, Inbred ICR An inbred strain of mouse that is used as a general purpose research strain, for therapeutic drug testing, and for the genetic analysis of CARCINOGEN-induced COLON CANCER. Mice, Inbred ICRC,Mice, ICR,Mouse, ICR,Mouse, Inbred ICR,Mouse, Inbred ICRC,ICR Mice,ICR Mice, Inbred,ICR Mouse,ICR Mouse, Inbred,ICRC Mice, Inbred,ICRC Mouse, Inbred,Inbred ICR Mice,Inbred ICR Mouse,Inbred ICRC Mice,Inbred ICRC Mouse
D002478 Cells, Cultured Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others. Cultured Cells,Cell, Cultured,Cultured Cell
D000071497 Immunogenicity, Vaccine The capacity of VACCINES to stimulate the ADAPTIVE IMMUNE RESPONSE to produce antibodies and antigen-specific T-CELL responses. It is typically measured in vaccinated individuals in observational studies setting. Antigenicity, Vaccine,Vaccine Antigenicity,Vaccine Immunogenicity
D000084824 Hericium A genus of fungi in the family Hericiaceae, order Russulales, and phylum BASIDIOMYCOTA. Hericium fungi are basidiomycetes with distinctive white fruiting body that resembles icicles such as in lion's mane mushroom, Hericium erinaceus.
D000276 Adjuvants, Immunologic Substances that augment, stimulate, activate, potentiate, or modulate the immune response at either the cellular or humoral level. The classical agents (Freund's adjuvant, BCG, Corynebacterium parvum, et al.) contain bacterial antigens. Some are endogenous (e.g., histamine, interferon, transfer factor, tuftsin, interleukin-1). Their mode of action is either non-specific, resulting in increased immune responsiveness to a wide variety of antigens, or antigen-specific, i.e., affecting a restricted type of immune response to a narrow group of antigens. The therapeutic efficacy of many biological response modifiers is related to their antigen-specific immunoadjuvanticity. Immunoactivators,Immunoadjuvant,Immunoadjuvants,Immunologic Adjuvant,Immunopotentiator,Immunopotentiators,Immunostimulant,Immunostimulants,Adjuvant, Immunologic,Adjuvants, Immunological,Immunologic Adjuvants,Immunological Adjuvant,Adjuvant, Immunological,Immunological Adjuvants
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D000914 Antibodies, Viral Immunoglobulins produced in response to VIRAL ANTIGENS. Viral Antibodies
D016207 Cytokines Non-antibody proteins secreted by inflammatory leukocytes and some non-leukocytic cells, that act as intercellular mediators. They differ from classical hormones in that they are produced by a number of tissue or cell types rather than by specialized glands. They generally act locally in a paracrine or autocrine rather than endocrine manner. Cytokine
D017737 Macrophages, Peritoneal Mononuclear phagocytes derived from bone marrow precursors but resident in the peritoneum. Peritoneal Macrophages,Macrophage, Peritoneal,Peritoneal Macrophage
D051379 Mice The common name for the genus Mus. Mice, House,Mus,Mus musculus,Mice, Laboratory,Mouse,Mouse, House,Mouse, Laboratory,Mouse, Swiss,Mus domesticus,Mus musculus domesticus,Swiss Mice,House Mice,House Mouse,Laboratory Mice,Laboratory Mouse,Mice, Swiss,Swiss Mouse,domesticus, Mus musculus

Related Publications

Zhe Ren, and Yang Luo, and Zhen Meng, and Junwen Zhang, and Ruihong Yu, and Mengke Sun, and Ting Xu, and Jian Li, and Yufang Ma, and Yifan Huang, and Tao Qin
July 1994, Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine,
Zhe Ren, and Yang Luo, and Zhen Meng, and Junwen Zhang, and Ruihong Yu, and Mengke Sun, and Ting Xu, and Jian Li, and Yufang Ma, and Yifan Huang, and Tao Qin
May 2007, Bioelectrochemistry (Amsterdam, Netherlands),
Zhe Ren, and Yang Luo, and Zhen Meng, and Junwen Zhang, and Ruihong Yu, and Mengke Sun, and Ting Xu, and Jian Li, and Yufang Ma, and Yifan Huang, and Tao Qin
December 2023, Materials (Basel, Switzerland),
Zhe Ren, and Yang Luo, and Zhen Meng, and Junwen Zhang, and Ruihong Yu, and Mengke Sun, and Ting Xu, and Jian Li, and Yufang Ma, and Yifan Huang, and Tao Qin
February 2015, Journal of nanoscience and nanotechnology,
Zhe Ren, and Yang Luo, and Zhen Meng, and Junwen Zhang, and Ruihong Yu, and Mengke Sun, and Ting Xu, and Jian Li, and Yufang Ma, and Yifan Huang, and Tao Qin
January 2010, Nanotechnology,
Zhe Ren, and Yang Luo, and Zhen Meng, and Junwen Zhang, and Ruihong Yu, and Mengke Sun, and Ting Xu, and Jian Li, and Yufang Ma, and Yifan Huang, and Tao Qin
January 2010, Analytical and bioanalytical chemistry,
Zhe Ren, and Yang Luo, and Zhen Meng, and Junwen Zhang, and Ruihong Yu, and Mengke Sun, and Ting Xu, and Jian Li, and Yufang Ma, and Yifan Huang, and Tao Qin
December 2018, Royal Society open science,
Zhe Ren, and Yang Luo, and Zhen Meng, and Junwen Zhang, and Ruihong Yu, and Mengke Sun, and Ting Xu, and Jian Li, and Yufang Ma, and Yifan Huang, and Tao Qin
July 2009, Talanta,
Zhe Ren, and Yang Luo, and Zhen Meng, and Junwen Zhang, and Ruihong Yu, and Mengke Sun, and Ting Xu, and Jian Li, and Yufang Ma, and Yifan Huang, and Tao Qin
April 2016, Food chemistry,
Zhe Ren, and Yang Luo, and Zhen Meng, and Junwen Zhang, and Ruihong Yu, and Mengke Sun, and Ting Xu, and Jian Li, and Yufang Ma, and Yifan Huang, and Tao Qin
May 2009, Toxicological sciences : an official journal of the Society of Toxicology,
Copied contents to your clipboard!