Biomaterial Database

A rapid and sensitive gas chromatographic analysis of meprobamate or carisoprodol in urine and plasma. 1988

P Kintz, and P Mangin, and A A Lugnier, and A J Chaumont

Institute de Médicine Légale, Strasbourg, France.

A method for the identification and quantification of meprobamate or carisoprodol in plasma by GC/FID is presented. The method employs vinylbarbital as the internal standard and requires no derivatization. After a single extraction, analysis is achieved in 7 min. This method is thus rapid, sensitive, reproducible, selective, and applicable to forensic and clinical toxicological analyses.

UI	MeSH Term	Description	Entries
D008620	Meprobamate	A carbamate with hypnotic, sedative, and some muscle relaxant properties, although in therapeutic doses reduction of anxiety rather than a direct effect may be responsible for muscle relaxation. Meprobamate has been reported to have anticonvulsant actions against petit mal seizures, but not against grand mal seizures (which may be exacerbated). It is used in the treatment of ANXIETY DISORDERS, and also for the short-term management of INSOMNIA but has largely been superseded by the BENZODIAZEPINES. (From Martindale, The Extra Pharmacopoeia, 30th ed, p603)	Dapaz,Equanil,Meprospan,Miltown,Méprobamate Richard,Tranmep,Visano
D002328	Carisoprodol	A centrally acting skeletal muscle relaxant whose mechanism of action is not completely understood but may be related to its sedative actions. It is used as an adjunct in the symptomatic treatment of musculoskeletal conditions associated with painful muscle spasm. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1202)	Carisoprodate,Isobamate,Isomeprobamate,Isopropylmeprobamate,Carisoma,Mio Relax,Soma,Somalgit,Soprodol,Vanadom
D002849	Chromatography, Gas	Fractionation of a vaporized sample as a consequence of partition between a mobile gaseous phase and a stationary phase held in a column. Two types are gas-solid chromatography, where the fixed phase is a solid, and gas-liquid, in which the stationary phase is a nonvolatile liquid supported on an inert solid matrix.	Chromatography, Gas-Liquid,Gas Chromatography,Chromatographies, Gas,Chromatographies, Gas-Liquid,Chromatography, Gas Liquid,Gas Chromatographies,Gas-Liquid Chromatographies,Gas-Liquid Chromatography
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man