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The ablation of the hypophysis does not disturb the basic waking-sleep cycle. Further, this intervention fails to modify the recovery of sleep after instrumental paradoxical sleep deprivation as well as after injection of 5-hydroxytryptophan in parachlorophenylalanine-pretreated insomniac cats. These results demonstrate that the hypophysis does not play a significant role in sleep mechanisms. We discuss these data in view of a possible regulation of the sleep-waking cycle by hypothalamo-hypophyseal hormones.
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