-transparent.png){kind=logo}
Somatomedin-C is present in human and other animal wound fluids. Somatomedin-C has previously been shown to be synthesized by fibroblasts. Our data shows that at least part of the wound fluid somatomedin-C comes from local wound synthesis. This somatomedin-C has the capability of acting as an autocrine in further stimulating the proliferation of fibroblasts. In addition, somatomedin-C has been shown to stimulate collagen synthesis by fibroblasts. Wound fluid also contains a somatomedin carrier protein; however, our evidence is that association between the carrier protein and somatomedin-C is much weaker than normal and, thus, wound fluid somatomedin that is bound to carrier protein is much more "available" for biologic action. An understanding of the role of somatomedins in normal wound healing might be able to help us understand abnormalities of the repair process such as keloid formation.
E M Spencer, and
G Skover, and
T K Hunt
February 2011,
International wound journal,
E M Spencer, and
G Skover, and
T K Hunt
January 2013,
PloS one,
E M Spencer, and
G Skover, and
T K Hunt
May 2024,
Journal of wound care,
E M Spencer, and
G Skover, and
T K Hunt
March 2006,
Advances in skin & wound care,
E M Spencer, and
G Skover, and
T K Hunt
January 2005,
Archivum immunologiae et therapiae experimentalis,
E M Spencer, and
G Skover, and
T K Hunt
May 2003,
Kidney international. Supplement,
E M Spencer, and
G Skover, and
T K Hunt
October 1998,
Journal of investigative medicine : the official publication of the American Federation for Clinical Research,
E M Spencer, and
G Skover, and
T K Hunt
September 2011,
Pituitary,
E M Spencer, and
G Skover, and
T K Hunt
December 2005,
Otolaryngologic clinics of North America,
E M Spencer, and
G Skover, and
T K Hunt
July 2011,
American journal of reproductive immunology (New York, N.Y. : 1989),
