BIOMAT Database Logo BIOMAT Database Logo

Detection of bone marrow edema in osteonecrosis of the femoral head using virtual noncalcium dual-energy computed tomography. 2021

Tianzi Zuo, and Yingmin Chen, and Hongming Zheng, and Xiuchuan Jia, and Yunfeng Bao, and Yuhang Wang, and Ling Li, and Xiaoying Huang
Department of Radiology, Hebei General Hospital, 348 Heping West Road, Shijiazhuang, 050000, Hebei, China. Electronic address: 279248872@qq.com.

OBJECTIVE To determine the diagnostic performance of virtual noncalcium (VNCa) dual-energy computed tomography (DECT) in the detection of bone marrow edema (BME) in participants with osteonecrosis of the femoral head (ONFH). METHODS In this prospective study, 24 consecutive participants (15 men, 9 women; mean age, 44 years, range, 21-72 years) diagnosed with ONFH who underwent DECT and magnetic resonance imaging (MRI) between September 2019 and January 2020 were involved. Two independent readers visually evaluated color-coded VNCa images using a binary classification (0 = normal bone marrow, 1 = BME). MRI served as the reference standard for the presence of BME. Interobserver agreement for the visual evaluation of VNCa DECT images was calculated with κ statistics. We determined computed tomography (CT) numbers on VNCa images and weighted-average CT sets using region-of-interest-based quantitative analysis. The t-test was used to compare the differences of CT values between BME areas and normal bone marrow areas. Receiver operating characteristic (ROC) curve was used to select an optimal CT values of VNCa images for detecting BME. A p value of <0.05 was considered as statistically significant. RESULTS The sensitivity, specificity, and accuracy of Reader 1 and Reader 2, respectively, in the identification of BME at DECT were 95 % and 89 % (18 and 17 of 19), 96 % and 96 % (25 and 25 of 26), and 93 % (43 and 42 of 45). Interobserver agreement was excellent (κ = 0.86). The VNCa CT numbers of the BME area and the normal bone marrow area were -28.6 (-17.9--39.4) HU and -97.9 (-91.3--104.4) HU, respectively, with statistical significance (t = -10.6, p < 0.001). The weighted-average CT numbers of the BME area and the normal bone marrow area were 152.4(122.2-182.7) HU and 121.1(103.6-183.6) HU, respectively, with no statistical significance (t = -2.0, p > 0.05). The area under the receiver operating characteristic curve was 0.99 in differentiation of the BME from normal bone marrow. A cut-off value of -57.2 HU yielded overall sensitivity, specificity, and accuracy, respectively, of 95 % (18 of 19), 100 % (26 of 26), and 98 % (44 of 45) detection of BME in participants with ONFH. CONCLUSIONS Visual and quantitative analyses of VNCa images shows excellent diagnostic performance for assessing BME in participants with ONFH.

UI MeSH Term Description Entries
D008279 Magnetic Resonance Imaging Non-invasive method of demonstrating internal anatomy based on the principle that atomic nuclei in a strong magnetic field absorb pulses of radiofrequency energy and emit them as radiowaves which can be reconstructed into computerized images. The concept includes proton spin tomographic techniques. Chemical Shift Imaging,MR Tomography,MRI Scans,MRI, Functional,Magnetic Resonance Image,Magnetic Resonance Imaging, Functional,Magnetization Transfer Contrast Imaging,NMR Imaging,NMR Tomography,Tomography, NMR,Tomography, Proton Spin,fMRI,Functional Magnetic Resonance Imaging,Imaging, Chemical Shift,Proton Spin Tomography,Spin Echo Imaging,Steady-State Free Precession MRI,Tomography, MR,Zeugmatography,Chemical Shift Imagings,Echo Imaging, Spin,Echo Imagings, Spin,Functional MRI,Functional MRIs,Image, Magnetic Resonance,Imaging, Magnetic Resonance,Imaging, NMR,Imaging, Spin Echo,Imagings, Chemical Shift,Imagings, Spin Echo,MRI Scan,MRIs, Functional,Magnetic Resonance Images,Resonance Image, Magnetic,Scan, MRI,Scans, MRI,Shift Imaging, Chemical,Shift Imagings, Chemical,Spin Echo Imagings,Steady State Free Precession MRI
D008297 Male Males
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D010020 Osteonecrosis Death of a bone or part of a bone, either atraumatic or posttraumatic. Aseptic Necrosis of Bone,Avascular Necrosis of Bone,Kienbock Disease,Necrosis, Aseptic, of Bone,Necrosis, Avascular, of Bone,Bone Necrosis,Kienbock's Disease,Kienboeck Disease,Kienboeck's Disease,Bone Aseptic Necrosis,Bone Avascular Necrosis,Bone Necroses,Kienboecks Disease,Necroses, Bone,Necrosis, Bone,Osteonecroses
D011446 Prospective Studies Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group. Prospective Study,Studies, Prospective,Study, Prospective
D001853 Bone Marrow The soft tissue filling the cavities of bones. Bone marrow exists in two types, yellow and red. Yellow marrow is found in the large cavities of large bones and consists mostly of fat cells and a few primitive blood cells. Red marrow is a hematopoietic tissue and is the site of production of erythrocytes and granular leukocytes. Bone marrow is made up of a framework of connective tissue containing branching fibers with the frame being filled with marrow cells. Marrow,Red Marrow,Yellow Marrow,Marrow, Bone,Marrow, Red,Marrow, Yellow
D004487 Edema Abnormal fluid accumulation in TISSUES or body cavities. Most cases of edema are present under the SKIN in SUBCUTANEOUS TISSUE. Dropsy,Hydrops,Anasarca
D005260 Female Females
D005270 Femur Head The hemispheric articular surface at the upper extremity of the thigh bone. (Stedman, 26th ed) Femoral Head,Femoral Heads,Femur Heads,Head, Femoral,Head, Femur
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man

Related Publications

Tianzi Zuo, and Yingmin Chen, and Hongming Zheng, and Xiuchuan Jia, and Yunfeng Bao, and Yuhang Wang, and Ling Li, and Xiaoying Huang
Dual-energy computed tomographic virtual noncalcium algorithm for detection of bone marrow edema in acute fractures: early experiences.
January 2014, Journal of computer assisted tomography,
Tianzi Zuo, and Yingmin Chen, and Hongming Zheng, and Xiuchuan Jia, and Yunfeng Bao, and Yuhang Wang, and Ling Li, and Xiaoying Huang
Axial Spondyloarthritis: Dual-Energy Virtual Noncalcium CT in the Detection of Bone Marrow Edema in the Sacroiliac Joints.
January 2019, Radiology,
Tianzi Zuo, and Yingmin Chen, and Hongming Zheng, and Xiuchuan Jia, and Yunfeng Bao, and Yuhang Wang, and Ling Li, and Xiaoying Huang
Feasibility of bone marrow edema detection using dual-energy cone-beam computed tomography.
March 2024, Medical physics,
Tianzi Zuo, and Yingmin Chen, and Hongming Zheng, and Xiuchuan Jia, and Yunfeng Bao, and Yuhang Wang, and Ling Li, and Xiaoying Huang
Detection of Bone Marrow Edema in Nondisplaced Hip Fractures: Utility of a Virtual Noncalcium Dual-Energy CT Application.
September 2017, Radiology,
Tianzi Zuo, and Yingmin Chen, and Hongming Zheng, and Xiuchuan Jia, and Yunfeng Bao, and Yuhang Wang, and Ling Li, and Xiaoying Huang
Detection of Bone Marrow Edema in Nondisplaced Hip Fractures: Utility of a Virtual Noncalcium Dual-Energy CT Application.
September 2017, Radiology,
Tianzi Zuo, and Yingmin Chen, and Hongming Zheng, and Xiuchuan Jia, and Yunfeng Bao, and Yuhang Wang, and Ling Li, and Xiaoying Huang
The Role of a Virtual Noncalcium Dual-Energy CT Application in the Detection of Bone Marrow Edema in Peripheral Osteomyelitis.
August 2022, Canadian Association of Radiologists journal = Journal l'Association canadienne des radiologistes,
Tianzi Zuo, and Yingmin Chen, and Hongming Zheng, and Xiuchuan Jia, and Yunfeng Bao, and Yuhang Wang, and Ling Li, and Xiaoying Huang
Detection of bone marrow edema in differential diagnoses of odontogenic cysts using dual-energy computed tomography.
December 2023, Oral and maxillofacial surgery,
Tianzi Zuo, and Yingmin Chen, and Hongming Zheng, and Xiuchuan Jia, and Yunfeng Bao, and Yuhang Wang, and Ling Li, and Xiaoying Huang
Dual-Energy Computed Tomography Virtual Noncalcium Technique in Diagnosing Osteoporosis: Correlation With Quantitative Computed Tomography.
January 2021, Journal of computer assisted tomography,
Tianzi Zuo, and Yingmin Chen, and Hongming Zheng, and Xiuchuan Jia, and Yunfeng Bao, and Yuhang Wang, and Ling Li, and Xiaoying Huang
[The detecting value of virtual non-calcium technique of dual-energy CT for bone marrow edema around nontraumatic osteonecrosis of the femoral head].
February 2024, Zhonghua yi xue za zhi,
Tianzi Zuo, and Yingmin Chen, and Hongming Zheng, and Xiuchuan Jia, and Yunfeng Bao, and Yuhang Wang, and Ling Li, and Xiaoying Huang
Meta-analysis of dual-energy computed tomography virtual non-calcium imaging to detect bone marrow edema.
October 2017, European journal of radiology,
Copied contents to your clipboard!