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The modified dual-label Schilling test, as further developed in kit form by Amersham International plc (UK), has been assessed in two separate centres. Since the outcome was similar in each centre, the results in 66 subjects were amalgamated. Using a cut-off point for the 58Co/57Co ratio of 0.52--as derived from studies in 10 healthy volunteers--to separate normal from abnormal results, the specificity of the test was 88%. However, the test's sensitivity in chronic pancreatic disease was only 50%: normal results occurred in 5 of 8 patients with pancreatic cancer (including 2 with steatorrhoea), and 9 of 21 with chronic pancreatitis (including 1 with steatorrhoea). The possible reasons for the test's poor sensitivity are discussed.
J W Leung, and
R A Frost, and
R Burgess, and
J M Braganza, and
D M Slater, and
P B Cotton
May 1989,
Gastroenterology,
J W Leung, and
R A Frost, and
R Burgess, and
J M Braganza, and
D M Slater, and
P B Cotton
May 1980,
Gastroenterology,
J W Leung, and
R A Frost, and
R Burgess, and
J M Braganza, and
D M Slater, and
P B Cotton
January 1952,
Revista espanola de las enfermedades del aparato digestivo y de la nutricion,
J W Leung, and
R A Frost, and
R Burgess, and
J M Braganza, and
D M Slater, and
P B Cotton
April 1982,
Taiwan yi xue hui za zhi. Journal of the Formosan Medical Association,
J W Leung, and
R A Frost, and
R Burgess, and
J M Braganza, and
D M Slater, and
P B Cotton
May 1978,
Nihon rinsho. Japanese journal of clinical medicine,
J W Leung, and
R A Frost, and
R Burgess, and
J M Braganza, and
D M Slater, and
P B Cotton
January 1975,
Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology,
J W Leung, and
R A Frost, and
R Burgess, and
J M Braganza, and
D M Slater, and
P B Cotton
October 1988,
Journal of the American Veterinary Medical Association,
J W Leung, and
R A Frost, and
R Burgess, and
J M Braganza, and
D M Slater, and
P B Cotton
November 1972,
Journal of medicinal chemistry,
J W Leung, and
R A Frost, and
R Burgess, and
J M Braganza, and
D M Slater, and
P B Cotton
January 1986,
Laboratornoe delo,
J W Leung, and
R A Frost, and
R Burgess, and
J M Braganza, and
D M Slater, and
P B Cotton
July 1973,
Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology,
