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Synthesis and Bioactivities of Novel 1,3,4-Thiadiazole Derivatives of Glucosides. 2021
Meihang Chen, and
Xun Zhang, and
Daowang Lu, and
Hairong Luo, and
Zengyan Zhou, and
Xufeng Qin, and
Wenneng Wu, and
Guoping Zhang
Colleges of Material and Chemistry Engineering, Tongren University, Tongren, China.
A series of novel 1,3,4-thiadiazole derivatives of glucosides were synthesized by the starting materials d-glucose and 5-amino-1,3,4-thiadiazole-2-thiol in good yields with employing a convergent synthetic route. The results of bioactivities showed that some of the target compounds exhibited good antifungal activities. Especially, compounds 4i showed higher bioactivities against Phytophthora infestans (P. infestans), with the EC50 values of 3.43, than that of Dimethomorph (5.52 μg/ml). In addition, the target compounds exhibited moderate to poor antibacterial activities against Xanthomonas oryzae pv. oryzae (Xoo), Xanthomonas campestris pv. citri (Xcc).
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