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Immunization of congenitally athymic (nu/nu) and adult thymectomized, irradiated bone marrow, reconstituted (TxBm) mice with DNP5-thymosin (dinitrophenylated-bovine thymosin fraction 5) was found to elcit IgM and IgG anti-DNP plaque-forming cells in these animals. Further studies indicated that this response was antigen specific and not due to polyclonal activation. Since the hormonal properties of the thymosin were retained following linkage with hapten and DNP-thymosin was immunogenic in CBA/N and CBA/N female X DBA/2 male)F1 male mice, animals previously shown to have an X-linked inability to respond to thymus-independent antigens, it was concluded that DNP-thymosin functions both as a hormone and as a T-dependent antigen in eliciting an immune response in nu/nu and TxBm mice. Additional support for this conclusion was provided by the demonstration that DNP-thymosin could specifically prime for and elicit an anamnestic response in nu/nu mice. These results indicate that further investigation of the immune activities of DNP-thymosin may provide valuable insight in characterizing the maturation of helper T cells and their subsequent interaction with B cells.
A Ahmed, and
A H Smith, and
K W Sell, and
M E Gershwin, and
A D Steinberg, and
G B Thurman, and
A L Goldstein
February 1981,
Journal of immunology (Baltimore, Md. : 1950),
A Ahmed, and
A H Smith, and
K W Sell, and
M E Gershwin, and
A D Steinberg, and
G B Thurman, and
A L Goldstein
January 1988,
Advances in experimental medicine and biology,
A Ahmed, and
A H Smith, and
K W Sell, and
M E Gershwin, and
A D Steinberg, and
G B Thurman, and
A L Goldstein
December 1977,
Mycopathologia,
A Ahmed, and
A H Smith, and
K W Sell, and
M E Gershwin, and
A D Steinberg, and
G B Thurman, and
A L Goldstein
September 1979,
Journal of the Reticuloendothelial Society,
A Ahmed, and
A H Smith, and
K W Sell, and
M E Gershwin, and
A D Steinberg, and
G B Thurman, and
A L Goldstein
January 1975,
Birth defects original article series,
A Ahmed, and
A H Smith, and
K W Sell, and
M E Gershwin, and
A D Steinberg, and
G B Thurman, and
A L Goldstein
January 1977,
Annales d'immunologie,
A Ahmed, and
A H Smith, and
K W Sell, and
M E Gershwin, and
A D Steinberg, and
G B Thurman, and
A L Goldstein
December 1978,
Cellular immunology,
A Ahmed, and
A H Smith, and
K W Sell, and
M E Gershwin, and
A D Steinberg, and
G B Thurman, and
A L Goldstein
December 1971,
Nature: New biology,
A Ahmed, and
A H Smith, and
K W Sell, and
M E Gershwin, and
A D Steinberg, and
G B Thurman, and
A L Goldstein
February 1976,
Journal of the Reticuloendothelial Society,
A Ahmed, and
A H Smith, and
K W Sell, and
M E Gershwin, and
A D Steinberg, and
G B Thurman, and
A L Goldstein
March 1984,
Infection and immunity,
