Biomaterial Database

Distribution of serotonin immunoreactivity in the forebrain and midbrain of the lizard Gekko gecko. 1988

W J Smeets, and H W Steinbusch

Department of Anatomy, Faculty of Medicine, Vrije Universiteit, Amsterdam, The Netherlands.

The distribution of serotonin (5-hydroxytryptamine, 5-HT) in the forebrain and midbrain of the lizard Gekko gecko was studied by means of antibodies against serotonin. In the diencephalon, serotonin-immunoreactive (5-HTi) cell bodies were found in the hypothalamic periventricular organ and the ependymal wall of the infundibular recess. In the midbrain, 5-HTi cells were observed in the nucleus raphes superior and the lateral portion of the nucleus reticularis superior. In addition, 5-HTi cell bodies were found lateral to the ventral interpeduncular nucleus and around the ventral aspect of the medial longitudinal fasciculus. Serotonin-immunoreactive fibers and varicosities are present throughout the forebrain and the midbrain, but particularly in the nucleus accumbens, the septal area, the dorsal cortex, the dorsal thalamus, the lateral geniculate body, the ventromedial hypothalamic nucleus, the pretectal nucleus, and the basal optic nucleus. The medial habenular nucleus contains a dense 5-HTi plexus that shows a patchlike pattern. A laminar organization of 5-HTi fibers and varicosities is present in the midbrain tectum. When compared with data obtained in other vertebrates, the present study has confirmed that in the phylogenetic series fishes-amphibians-reptiles-birds-mammals there appears to be (1) a gradual decrease in the number of cerebrospinal-fluid-contacting serotoninergic cells in the hypothalamic periventricular layer and (2) a remarkable increase in number of serotoninergic cells in the midbrain tegmentum. As in mammals, a strong serotoninergic innervation of structures related to sensory, in particular visual, pathways could be recognized.

UI	MeSH Term	Description	Entries
D007150	Immunohistochemistry	Histochemical localization of immunoreactive substances using labeled antibodies as reagents.	Immunocytochemistry,Immunogold Techniques,Immunogold-Silver Techniques,Immunohistocytochemistry,Immunolabeling Techniques,Immunogold Technics,Immunogold-Silver Technics,Immunolabeling Technics,Immunogold Silver Technics,Immunogold Silver Techniques,Immunogold Technic,Immunogold Technique,Immunogold-Silver Technic,Immunogold-Silver Technique,Immunolabeling Technic,Immunolabeling Technique,Technic, Immunogold,Technic, Immunogold-Silver,Technic, Immunolabeling,Technics, Immunogold,Technics, Immunogold-Silver,Technics, Immunolabeling,Technique, Immunogold,Technique, Immunogold-Silver,Technique, Immunolabeling,Techniques, Immunogold,Techniques, Immunogold-Silver,Techniques, Immunolabeling
D008116	Lizards	Reptiles within the order Squamata that generally possess limbs, moveable EYELIDS, and EXTERNAL EAR openings, although there are some species which lack one or more of these structures.	Chameleons,Geckos,Chameleon,Gecko,Lizard
D008297	Male		Males
D008636	Mesencephalon	The middle of the three primitive cerebral vesicles of the embryonic brain. Without further subdivision, midbrain develops into a short, constricted portion connecting the PONS and the DIENCEPHALON. Midbrain contains two major parts, the dorsal TECTUM MESENCEPHALI and the ventral TEGMENTUM MESENCEPHALI, housing components of auditory, visual, and other sensorimoter systems.	Midbrain,Mesencephalons,Midbrains
D009412	Nerve Fibers	Slender processes of NEURONS, including the AXONS and their glial envelopes (MYELIN SHEATH). Nerve fibers conduct nerve impulses to and from the CENTRAL NERVOUS SYSTEM.	Cerebellar Mossy Fibers,Mossy Fibers, Cerebellar,Cerebellar Mossy Fiber,Mossy Fiber, Cerebellar,Nerve Fiber
D001931	Brain Mapping	Imaging techniques used to colocalize sites of brain functions or physiological activity with brain structures.	Brain Electrical Activity Mapping,Functional Cerebral Localization,Topographic Brain Mapping,Brain Mapping, Topographic,Functional Cerebral Localizations,Mapping, Brain,Mapping, Topographic Brain
D005260	Female		Females
D005625	Frontal Lobe	The part of the cerebral hemisphere anterior to the central sulcus, and anterior and superior to the lateral sulcus.	Brodmann Area 8,Brodmann's Area 8,Frontal Cortex,Frontal Eye Fields,Lobus Frontalis,Supplementary Eye Field,Area 8, Brodmann,Area 8, Brodmann's,Brodmanns Area 8,Cortex, Frontal,Eye Field, Frontal,Eye Field, Supplementary,Eye Fields, Frontal,Frontal Cortices,Frontal Eye Field,Frontal Lobes,Lobe, Frontal,Supplementary Eye Fields
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D012701	Serotonin	A biochemical messenger and regulator, synthesized from the essential amino acid L-TRYPTOPHAN. In humans it is found primarily in the central nervous system, gastrointestinal tract, and blood platelets. Serotonin mediates several important physiological functions including neurotransmission, gastrointestinal motility, hemostasis, and cardiovascular integrity. Multiple receptor families (RECEPTORS, SEROTONIN) explain the broad physiological actions and distribution of this biochemical mediator.	5-HT,5-Hydroxytryptamine,3-(2-Aminoethyl)-1H-indol-5-ol,Enteramine,Hippophaine,Hydroxytryptamine,5 Hydroxytryptamine